1采用荧光膜片钳研究昆虫生理毒理

2 绿色农药合理创制

1993-1996 青岛大学应用化学系

1996-2000 山东三联集团

2000-2003 湖南科技大学化学院研究生

2003-2006 南开大学化学院元素所博士生

2006-2010 南开大学化学学院元素所讲师

2010-2021 南开大学化学学院元素所副研究员

2021-至今 南开大学化学学院元素所教授

2004，南开大学研究生 一等求是奖学金

2005，陈茹玉奖学金度

2006届优秀研究生毕业生

主持：

1. 国家自然科学基金面上项目：夜蛾科昆虫1,4,5-三磷酸肌醇受体的精细调控与靶向杀虫剂的创制研究(项目编号：31972287, 20200101-20231231, 在研)。

2 国家自然科学基金，二酰胺类杀虫剂对鳞翅目昆虫神经元钙信号调控研究（项目编号：31370039， 20130101-20171231）。

3 国家自然科学基金，酰胺类杀虫剂对昆虫新靶标细胞内钙离子调控研究（项目编号：31000861， 20110101-20131231）。

4 天津市自然科学基金，靶向昆虫胶原细胞钙通道调控剂的设计合成及机制（项目编号：16JCYBJC29400, 201603-201903）。

5 天津市自然科学基金， 靶向细胞钙通道的N-糖基酰胺设计合成及作用机制研究（项目编号：11JCYBJC08600， 201103-201403）。

6 南开大学基本科研业务费，酰胺类杀虫剂对昆虫钙离子通道的调控及建立以钙离子通道为作用靶标的杀虫剂筛选平台，201006-201205。

7 南开大学创新基金，具有杀虫活性的糖类化合物的设计合成及生物活性测试， 200701-2007012。

8. 小分子靶向药物研究与创制湖南省重点实验室开放基金：双酰胺类化合物设计合成及抗肿瘤活性(项目编号：2019CG04)。

参与：

1. 国家重点研发计划：化学肥料和农药减施增效综合技术研发专项， 农业生物药物分子靶标发现与绿色药物分子设计， 课题五：昆虫调控相关的候选药物研究及产品创新201701－202012。科研骨干。

2. 国家重点研发计划：化学肥料和农药减施增效综合技术研发, 高效低风险小分子农药和制剂研发与示范, 课题一：高效低风险小分子杀虫剂研发与示范， 201801－202012，2018YFD0200100。科研骨干

代表论文：

1）Zhao Y.Y., Gao L., Li H.G., Sun P.W., Meng F.F., Zhang Y., Xie Y.T., Sun B.Q., Zhou S., Ma Y., Xiong L.X., Yang N, Li Y.X.⁎, Li Z.M.⁎. Synthesis, insecticidal activities, and structure−Activity relationship of phenylpyrazole derivatives containing a fluoro-substituted benzene moiety. J. Agric. Food Chem., 2020, 68: 11282−11289. 

2）Wu C.C., Yu X. B., Wang B. L., Yu, Liu J.B., Meng F.F., Zhao Y.Y., Xiong L. X., Yang N, Li Y.X.⁎, Li Z.M.⁎. Synthesis, insecticidal evaluation, and 3D-QASR of novel anthranilic diamide derivatives containing N‑arylpyrrole as potential ryanodine receptor activators. J. Agric. Food Chem., 2020, 68: 9319−9328. 

3）Zhao Y. Y., Li H. G., Sun P.W., Gao L., Liu J.B., Zhou S., Xiong L. X., Yang N, Li Y.X.⁎, Li Z.M.⁎. Synthesis, biological activities, and SAR studies of novel 1-(2-chloro-4,5-difluorophenyl)-1H-pyrazole derivatives. Bioorg. Med. Chem. Lett., 2020, 30: 127535.

4）Li Z.Z., Jiang H., Liu S. N., Li Y.X.*, Yuchi Z.G.*, Gao Q.Z.*. Ryanodine receptor-targeting small molecule fluorescent probes enables non-isotopic labeling and efficient drug screening for green insecticides. Analytica Chimica Acta, 2020, 1108: 108-117. 

5）Li F. Y., Wang Y.H., Liu J.B.*, Li Y.X.⁎. Synthesis, insecticidal evaluation and mode of action of novel anthranilic diamide derivatives containing sulfur moiety as potential ryanodine receptor activators. Bioorg. Med. Chem., 2019, 27：769-776. 

6）Zhou Y.Y.*, Wei W., Zhu L.L., Li Y.X.⁎. Synthesis and bioactivities rvaluation of novel anthranilic diamides containing N-(tert-butyl)benzohydrazide moiety as potent ryanodine receptor activator. Chin. J. Chem., 2019, 37: 605—610.

7）Liu J.B., Li F.Y., Wang Y.H., Zhang H.X., Dong J.Y., Sun P.W., Li Y.X.*, Li Z.M.*. Synthesis, biological activities and 3D-QSAR studies of (R)-2-phenyl-4,5-dihydrothiazole-4-carboxamide derivatives containing a sulfur ether moiety. Chin. Chem. Lett., 2019, 30: 668-671. 

8）Chen W.*, Li Y.X., Zhou Y.Y., Ma Y., Li Z.M.. Design, synthesis and SAR study of novel sulfonylurea derivatives containing arylpyrimidine moieties as potential anti-phytopathogenic fungal agents. Chin. Chem. Lett., 2019, 30: 2160-2162. 

9）Liu J.B., Li F.Y., Li Y.X.*, Zhang X.L., Hua X.W., Xiong L.X., Li Z.M.*. Synthesis, insecticidal evaluation and 3D-QSAR study of novel anthranilic diamide derivatives as potential ryanodine receptor modulators. Pest Manag. Sci.. 2019, 75: 1034–1044. 

10）Liu J.B., Li F.Y., Dong J.Y., Li Y.X.⁎, Zhang X.L., Wang Y.H., Xiong L.X., Li Z.M.⁎,  Anthranilic diamides derivatives as potential ryanodine receptor modulators: synthesis, biological evaluation and structure activity relationship. Bioorg. Med. Chem., 2018, 26：3541–3550. 

11）Zhou Y.Y., Wei W., Zhu L.L., Li Y.X.*, Li Z.M.*. Synthesis and insecticidal activity study of novel anthranilic diamides analogs containing a diacylhydrazine bridge as effective Ca2+ modulators. Chem. Biol. Drug Des., 2018, 92:1914–1919.

12）Cheng D.D., Wei W., Li Y.X.* , Hua X.W., Zhou Y.Y., Liu J.B., Li Y.H., Yu S.J., Xiong L.X., Li Z.M.*，Design, synthesis and biological activities of novel 4,5-disubstituted-3-S- (β-D-acetylglycosyl)-1,2,4-triazole derivatives. Chem. Res. Chin. Univ., 2017, 33(5): 758-764.  

13）Liu J.B., Li Y.X.*, Zhang X.L., Hua X.W., Wu C.C., Wei W., Wan Y.Y., Cheng D.D., Xiong L.X., Yang N., Song H.B., Li Z.M.*，Novel anthranilic diamide scaffolds containing N substituted phenylpyrazole as potential ryanodine receptor activators. J. Agric. Food Chem., 2016, 64: 3697−3704. 

14）Li Y.X.*, Lian X.H., Wan Y.Y., Wang D.Y., Chen W., Di F.J., Wu W.J., Li Z.M.*，Modulation of the Ca2+ signaling pathway by celangulin I in the central neurons of Spodoptera exigua. Pestic. Biochem. Phys., 2016, 127: 76-81. 

15）Wan Y.Y., Wei W., Chen Y.W., Liu J.B., Cheng D.D., Xiong L.X., Yu S.J., Li Y.X.*, Li Z.M.*, Synthesis and bioactivity of (S, S)-2,8-diazabicyclo [4.3.0] nonane containing benzimidazole moiety. 农药学学报, 2016, 18(3): 291-298.  

16）Li Y.X.*, Di F.J., Wang D.Y., Chen W., Wan Y.Y., Li Z.M.*，Design and synthesis of 1-glycosyl-4-{N-[(2′-morpholinethoxy)-phenyl]aminomethyl}-1H-1,2,3-triazoles as calcium activators. Chem. Res. Chin. Univ., 2015, 31(6): 952-957.

17）Liu J.B., Li Y.X.*, Chen Y.W., Hua X.W., Wan Y.Y., Wei W., Song H.B., Yu S.J., Zhang X., Li Z.M.*. Design, synthesis, antifungal activities and SARs of (R)-2-aryl-4,5-dihydrothiazole -4-carboxylic acid derivatives. Chin. J. Chem., 2015, 33(11): 1269-1275. 

18）Zhou Y.Y., Wang B.L., Di F.J., Xiong L.X., Yang N., Li Y.Q., Li Y.X.*, Li Z.M.*，Synthesis and biological activities of 2,3-dihydro-1,3,4- oxadiazole compounds and its derivatives as potential activator of ryanodine receptors. Bioorg. Med. Chem. Lett., 2014, 24(10): 2295-2299.

19）Mao M.Z., Li Y.X., Zhou Y.Y., Zhang X.L., Liu Q.X., Di F.J., Song H.B., Xiong L.X., Li Y.Q., Li Z.M.*，Synthesis and insecticidal evaluation of novel N‑pyridylpyrazole carboxamides containing an amino acid methyl ester and their analogues. J Agric. Food Chem., 2014, 62:1536−1542. 

20）Mao M.Z., Li Y.X.*, Zhou Y.Y., Yang X.P., Zhang X.L., Zhang X., Li Z.M.*. Synthesis and biological activity of novel 1-substituted phenyl(glycosyl)-4-{4-[(4,6-dimethoxy)pyrimidin-2-yl]piperazin-1-yl}methyl-1H-1,2,3-triazoles. Chem. Res. Chin. Univ. 2013, 29(5): 900—905.

21）Mao M.Z., Li Y.X*., Liu Q., Zhou Y.Y., Zhang X., Xiong L.X., Li Y.M., Li Z.M.*. Synthesis and Insecticidal Evaluation of Novel N- pyridylpyrazole carboxamides Containing Cyano Substituent in the ortho-position. Bioorg. Med. Chem. Lett., 2013, 23(1): 42-46.

22）Zhou Y.Y., Li Y.X.*, Li Y.M., Yang X.P., Chen W., Mao M.Z., Liu T.W., Xiong L.X., Li Z.M.*, Design, synthesis and structure-activity of N-glycosyl-1-pyridyl-1H-pyrazole -5-carboxamide as inhibitors of calcium channel. Chem. Res. Chin. Univ., 2013, 29(2): 249-255.

23）Zhou Y.Y., Feng Q., Di F.J., Liu Q.X., Wang D.Y., Chen Y.W., Xiong L.X., Song H.B., Li Y.X.*, Li Z.M.*. Synthesis and insecticidal activities of 2,3-dihydroquinazolin-4(1H)-one derivatives targeting calcium channel, Bioorg. Med. Chem., 2013, 21: 4968–4975. 

24）Zhang J.F., Xu J.Y., Wang B.L, Li Y.X.*, Xiong L.X., Li Y.Q., Ma Y., Li Z.M.*. Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea，J. Agric. Food Chem., 2012, 60(31): 7565-7572. 

25）Yan T., Li Y.X. *, Li Y.Q., Wang D.Y., Chen W., Liu Z., Li Z.M.*，Synthesis and insecticidal activities of novel phthalic acid diamides. Chin. J. Chem., 2012, 30(7): 1445-1452.

26）Mao M. Z., Li Y. X.*,Zhou Y. Y., Chen W., Liu T. W., Yu S. J.,Wang S. H., Li Z. M.*. Synthesis and biological activity of novel 1-substituted phenyl-4-[N-[(2-morpholinothoxy) phenyl]aminomethyl]-1H-1,2,3-triazoles, Chem. Biol. Drug. Des., 2011, 78: 695-699.

27）Li Y.X., Mao M.Z., Li Y.M.*, Xiong L.X., Li Z.M., Xu J.Y., Modulations of high-voltage activated Ca2+ channels in the central neurones of Spodoptera exigua by chlorantraniliprole. Physiol. Entomol., 2011, 36: 230–234. 昆虫二区

28）Li Y.X.*, Chen W., Yang X.P., Yu G.P., Mao M.Z., Zhou Y.Y., Liu T.W., Li Z.M.*, Regioselective synthesis of novel 3-thiazolidine acetic acid derivatives from glycosido ureides. Chem. Biol. Drug. Des., 2011, 78: 969–978.

人才培养

指导硕士研究生五名，协助李正名教授指导硕士研究生9名。