1、新型药物分子的设计、合成与构效关系的研究

2、通过碳氢活化的方法构建新型杂环化合物

1983-1987年于河南大学化学系本科。

1987-1990年南开大学元素有机化学研究所硕士。

1990-1993年天津药业公司任职

1993-2000年天津乐基化学工业有限公司任职

2000-2002年天津中新药业集团股份有限公司任职。

2002年～至今，在南开大学元素有机化学研究所杨华铮教授课题组，从事除草剂的开发研究，于2005年6月获得农药学博士学位，2006年12月任职副研究员。

2015年7月-2016年8月 在加拿大麦基尔大学（McGill University)化学系李朝军院士课题组做访问学者，从事绿色化学方法学研究。

(1) Li, Hua-Bin; Li, Lei; Li, Jun-Xian; Han, Ting-Feng; He, Jing-Li; Zhu, You-Quan* Novel HPPD inhibitors: triketone 2H-benzo[b][1,4]oxazin-3(4H)-one analogs Pest Management Science (2017), DOI:10.1002/ps.4739

(2) Xu, Haizhen; Xie, Lifen; Han, Tingfeng; He, Jingli; Zhu, Youquan* Synthesis, herbicidal activities of novel triketone compounds containing 4-substituted cyclopentane-1,3-dione moiety Youji Huaxue (2017), 37(10), 2717-2724。

(3) Zhu, You-Quan*; Han, Ting-Feng; He, Jing-Li; Li, Man; Li, Jun-Xian; Zhu, Kun Route to Substituted Furan-2(5H)-ones from cyclo-Alkenecarboxylic Acids and Acrylates via C-H Activation Journal of Organic Chemistry (2017), 82(16), 8598-8603. 

(4) Zhu, You-Quan*; Li, Jun-Xian; Han, Ting-Feng; He, Jing-Li; Zhu, Kun Rh(III)-Catalyzed Regioselective Synthesis of Phthalides with Water as the Solvent European Journal of Organic Chemistry (2017), 2017(4), 806-811.

(5) Liu, Yun*; Ge, Wen-Hui; Zhu, You-Quan; Hu, Hua-You; Fan, Hui; Shi, Yan-Hui; Wu, Hui NIS-Induced Enone Difunctionalization for the Synthesis of Naphtho[2,3-b]furan-4,9-diones European Journal of Organic Chemistry (2017), 2017(3), 551-559 (1) 

(6) Liu, Yun*; Ge, Wenhui; Han, Junwen; Zhu, Youquan; Shi, Yanhui; Wu, Hui DABCO-catalyzed three-component reaction for the synthesis of naphtho[2,3-b]thiophene-4,9-diones Tetrahedron Letters (2017), 58(27), 2665-2669.

(7) Zhu, You-Quan; Liu, Yun; Wang, Hai ning; Liu, Wen bo; Li, Chao-Jun* Reaction of alkenecarboxylic acids with isocyanates via rhodium(III)-catalyzed C-H activation: a versatile route to cyclic imides Organic Chemistry Frontiers (2016), 3(8), 971-974.

(8) Liu, Wenbo; Zhu, Youquan; Li, Chao-Jun* Pd-Catalyzed Homo Cross-Dehydrogenative Coupling of 2-Arylpyridines by Using I2 as the Sole Oxidant Synthesis (2016), 48(11), 1616-1621.

(9) Zhu, Youquan*; Zhang, Haili; Wang, Danyang; Li, Lei; Xu, Han; Li, Huabin; Ma, Yuan. Design, Synthesis and Biological Evaluation of Novel N-(4-([2,2':5',2''-Terthiophen]-5-yl)-2-methylbut-3-yn-2-yl) Benzamide Derivatives Chinese Journal of Chemistry (2015), 33(2), 268-276.

(10) Xu, Hai-zhen; Xie, Li-fen; Zhang, Hai-li; Li, Lei; Ma, Yuan; Zhu, You-quan* Synthesis, dimer crystal structure and herbicidal activity of 2-(4-ethoxybenzoyl)cyclopentane-1,3-dione Chinese Journal of Structural Chemistry (2014), 33(10), 1451-1454.

(11) Zhu, You-quan*; Zhang, Hai-li; Li, Lei; Xu, Hai-zhen Design, synthesis, and anti-tobacco mosaic virus activity of novel α-terthienyl derivatives Abstracts of Papers, 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14, 2014 (2014), AGRO-747.

(12) Zhu, You-quan*; Zhang, Jin; Yuan, Yan-wei; Xie, Li-fen; Xu, Hai-zhen; Zou, Xiao-mao; Yang, Hua-zheng Synthesis and herbicidal activities of novel 3-(α-hydroxymethylene)pyrrolidine-2,4-dione derivatives containing a cyclopropane moiety Journal of Heterocyclic Chemistry (2013), 50(2), 202-205.

(13) Zhu, Youquan*; Liu, Pei; Wang, Danyang; Zhang, Jin; Cheng, Jie; Ma, Yuan; Zou, Xiaomao; Yang, Huazheng. Synthesis and Bioactivities of Novel N-(4-(2-Aryloxythiazol-5-yl)-3-butyn-2-yl)benzamides Chinese Journal of Chemistry (2013), 31(2), 173-181.

(14) Xu, Haizhen; Zhu, Youquan*; Xie, Lifen; Wang, Xiaofang Design, synthesis and bioactivity of novel 2-aroyl-5-alkylcyclopentanone derivatives Youji Huaxue (2013), 33(1), 143-147。

(15) Zhu, Youquan*; Wang, Danyang; Yuan, Yanwei; Ma, Yuan; Zou, Xiaomao; Yang, Huazheng Design, synthesis and bioactivity of novel 2-aryl-4-alkylthia-zole-5-carboxylic acid derivatives Youji Huaxue (2012), 32(11), 2115-2121.

(16) Xu, Han; Zhu, You-Quan; Zou, Xiao-Mao; Liu, Bin; Wang, Yong; Hu, Fang-Zhong; Yang, Hua-Zheng* Synthesis and herbicidal activities of novel 3-(substituted benzyloxy or phenoxy)-6-methyl-4-(3-trifluoromethylphenyl) pyridazine derivatives Pest Management Science (2012), 68(2), 276-284.

(17) Synthesis and biological activity of novel 3-[α-hydroxy(indol-3-yl)-methylene]-pyrrolidine-2,4-dione derivatives. Youji Huaxue (2010), 30(8), 1207-1211.

(18) Zhu, Youquan*; Liu, Cui; Zhang, Jin; Yuan, Yanwei; Zhu, Ran; Zou, Xiaomao; Hu, Fangzhong; Yang, Huazheng Synthesis and bioactivities of 2-cyanoalkoxycarbonyl-methyleneimidazolidine Youji Huaxue (2010), 30(7), 1088-1092.

(19) Zhu, Youquan; Liu, Weimin; Liu, Bin; Hu, Fangzhong; Zhu, Ran; Zou, Xiaomao; Yang, Huazheng*. Design, synthesis and quantitative structure-activity relationship study of herbicidal analogues of 3-(2-pyrimidinyl)-2,3-dihydro-1,3,4- oxadiazol-2-ones Youji Huaxue (2009), 29(4), 638-642.

(20) Li, Hua-bin; Zhu, You-quan; Song, Xiao-wei; Hu, Fang-zhong; Liu, Bin; Li, Yong-hong; Niu, Zi-xia; Liu, Pei; Wang, Zhi-hong; Song, Hai-bin; Zou, Xiao-Mao; Yang Hua-Zheng*. Novel Protoporphyrinogen Oxidase Inhibitors: 3H-Pyrazolo[3,4-d][1,2,3]triazin-4-one Derivatives Journal of Agricultural and Food Chemistry (2008), 56(20), 9535-9542.

(21) Zhu, You-Quan; Hu, Xu-Hong; Xu, Han; Wang, Yong; Zou, Xiao-Mao; Yang, Hua-Zheng* Synthesis and QSAR study of novel 8-(3-(trifluoromethyl) phenyl)-6-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-ones ARKIVOC (Gainesville, FL, United States) (2008), (12), 30-41.

(22) Zhu, You-quan; Wu, Chao; Li, Hua-bin; Zou, Xiao-mao; Si, Xue-kai; Hu, Fang-zhong; Yang, Hua-zheng*. Design, synthesis, and quantitative structure-activity relationship study of herbicidal analogues of pyrazolo[5,1-d][1,2,3,5]tetrazin-4(3H)ones. Journal of Agricultural and Food Chemistry 2007, 55(4), 1364-1369.

(23) Zhu, You-Quan; Zou, Xiao-Mao; Li, Gong-Chun; Yao, Chang-Sheng; Si, Xue-Kai; Yang, Hua-Zheng*. Synthesis and herbicidal evaluation of 3-substituted benzyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione derivatives. Youji Huaxue (2007), 27(6), 753-757.

(24) Zhu, You-Quan; Si, Xue-Kai; Zou, Xiao-Mao; Liu, Bin; Yang, Hua-Zheng* Synthesis and herbicidal evaluation of novel 3-(hydroxymethylene)-2,4-pyrrolidinedione Youji Huaxue (2007), 27(3), 385-390.

(25) Zhu, You-Quan; Liu, Pei; Si, Xue-Kai; Zou, Xiao-Mao; Liu, Bin; Song, Hai-Bin; Yang, Hua-Zheng* A Quantitative Structure-Activity Relationship Study of Herbicidal Analogues of α-Hydroxy-Substituted 3-Benzylidenepyrrolidene-2,4-diones Journal of Agricultural and Food Chemistry (2006), 54(19), 7200-7205.

(26) Zhu, Youquan; Zou, Xiaomao; Hu, Fangzhong; Yao, Changsheng; Liu, Bin; Yang, Huazheng. Synthesis and Herbicidal Evaluation of Novel 3-[(α-Hydroxy-substituted)benzylidene]pyrrolidine-2,4-diones. Journal of Agricultural and Food Chemistry (2005), 53(24), 9566-9570.

(27) Zhu, You-Quan; Yao, Chang-Sheng; Zou, Xiao-Mao; Hu, Fang-Zhong; Liu, Bin; Li, Yong-Hong; Yang, Hua-Zheng*. The synthesis and herbicidal activity of 1-alkyl-3-(α-hydroxybenzylidene)pyrrolidine-2,4-diones. Molecules (2005), 10(2), 427-434.

(28) 杨华铮*,邹小毛, 朱有全,杨光富,胡方中,任雪玲,许寒,李华斌. 现代农药化学; 北京：化学工业出版社（本人负责第3篇第1、3、4、5、6、7、8、9、11、12、13章），字数1716000。2013.09.01

专利

(1) Zhu, Youquan; Li, Lei; Li, Junxian Preparation of 2-(6-nitro-3-oxa-2H-benzo[1,4]-triazine-7-hydroxy)cyclohexane- 1,3-diketone-containing compounds as herbicides. Faming Zhuanli Shenqing (2015), CN 104961704 A 20151007(已授权).

(2) Zhu, Youquan; Zhang, Haili; Li, Lei; Li, Junxian Herbicidal activity of 2-(2,2-dimethyl-7-fluoro-2H-benzoxazin-3 (4H)-on-6-yl)tetrazolone. Faming Zhuanli Shenqing (2015), CN 104610246 A 20150513.

(3) Zhu, Youquan; Li, Lei; Zhang, Haili; Li, Junxian. Herbicidal activity of 2-(2-ethyl-7-fluoro-benzoxazine-3(4H)-one-6-yl) tetrazolinone compounds. Faming Zhuanli Shenqing (2015), CN 104610245 A 20150513.

(4) Zhu, Youquan; Zhang, Haili; Wang, Danyang; Li, Lei. Preparation of N-(4-(2,2':5',2''-terthienyl-5-yl)-2-methylbut-3-yn-2-yl) benzamide compounds for inhibiting tobacco mosaic virus. Faming Zhuanli Shenqing (2014), CN 104045622 A 20140917(已授权)

(5) Zhu, Youquan; Ma, Yuan; Wang, Danyang. Preparation of 2,5-di(2-thienyl)thiazole derivative as larvicidal insecticides. Faming Zhuanli Shenqing (2013), CN 103467464 A 20131225(已授权)

(6) Zhu, Youquan; Wang, Xiaofang; Cheng, Jie; Zhang, Haili; Wang, Danyang. Preparation of cyano acrylamide compounds containing 2-aryloxypropylamino structure as agrochemical fungicides. Faming Zhuanli Shenqing (2013), CN 103408478 A 20131127

(7) Zhu, Youquan; Wang, Danyang; Cheng, Jie; Wang, Xiaofang; Zhang, Haili. Tetrazolinone derivative containing 7-fluoro-2-methylbenzoxazin-3-one as herbicide and its preparation. Faming Zhuanli Shenqing (2013), CN 103319471 A 20130925,

(8) Zhu, Youquan; Cheng, Jie; Wang, Xiaofang; Zhang, Haili; Wang, Danyang Cyano acrylate containing aryloxy propane-2-amino as agrochemical bactericide and its preparation. Faming Zhuanli Shenqing (2013), CN 103304459 A 20130918.

(9) Zhu, Youquan; Wang, Xiaofang; Cheng, Jie; Zhang, Haili; Wang, Danyang Preparation of cyanoacrylate compounds containing 2-aryloxypropylamino moiety as fungicides. Faming Zhuanli Shenqing (2013), CN 103304458 A 20130918

(10) Zhu, Youquan; Cheng, Jie; Wang, Xiaofang; Zhang, Haili; Wang, Danyang Cyano acrylamide containing aryloxy propane-2-amino as agrochemical bactericide and its preparation. Faming Zhuanli Shenqing (2013), CN 103304460 A(已授权).

(11) Zhu, Youquan; Wang, Danyang; Yuan, Yanwei; Cheng, Jie; Wang, Xiaofang 2-Benzoxazinone-5-cyclohexylaminocarbonyl tetrazolone with herbicidal activity. Faming Zhuanli Shenqing (2013), CN 102875540 A

(12) Zhu, Youquan; Zhang, Jin; Yuan, Yanwei; Xie, Lifen; Yang, Huazheng; Zou, Xiaomao; Hu, Fangzhong. Preparation of pyrrolidine-2,4-dione derivatives as herbicides. Faming Zhuanli Shenqing (2010), CN 101891669 A(已授权).

(13) Zhu, Youquan; Zhu, Ran; Yang, Huazheng; Xiao, Yuhong; Zou, Xiaomao; Hu, Fangzhong. Process for preparation of ethyl methyl(3-oxopropyl)phosphinate intermediate product for herbicide glufosinate. Faming Zhuanli Shenqing Gongkai Shuomingshu (2009), CN 101418013 A.

共培养硕士13名