1、靶向药物传递系统的研究

2、药物动力学与药物代谢

3、生物分析

4、先导化合物靶点及作用机制探

1999-2003 沈阳药科大学药学（理科基地）本科

2003-2005 沈阳药科大学药剂学硕士研究生

2005-2007 沈阳药科大学药剂学博士研究生

2007-2020 南开大学药学院

2020-今  南开大学化学院

曾主持并完成天津市自然基金项目2项；曾参加国家 “973”计划项目1项，国家自然科学基金（面上）项目3项。

1. Xiaonan Xi, Ning Liu, Qianqian Wang, Yahui Chu, Zheng Yin, Yahui Ding*, Yaxin Lu*, ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma. Cell Death & Disease 2019, 10, 757.

2. Xiaonan Xi, Yahui Chu, Ning Liu, Qianqian Wang, Zheng Yin, Yaxin Lu*, Yue Chen*. Joint bioinformatics analysis of underlying potential functions of hsa-let-7b-5p and core genes in human glioma. J Transl Med 2019, 17, 129.

3. Xiaonan Xi, Ning liu, Qianqian Wang, Haiting Wu, Haibo He, Linlin Wang, Tianjin Zhang, Liang sun, Zheng Yin, Yue Chen, Yaxin Lu*, Pharmacokinetics, Tissue Distribution and Excretion of ACT001 in Sprague-Dawley Rats and Metabolism of ACT001. J Chromatogr B 2018, 1104, 29-39.

4. Man Wang, Lei Liu, Zheng Yin*, Yaxin Lu*, Comparison of Two Online Extraction Systems and Development of the Online SPE-HPLC-DAD Method to Simultaneously Determine Ten b-amino Alcohol Drugs in Plasma. RSC Adv 2018, 8, 5816-5821.

5. Man Wang1, Ping Ma1, Xiaonan Xi1, Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Yaxin Lu*, Zheng Yin*, Online solid phase extraction and liquid chromatography-mass spectrometric determination of nucleoside drugs in plasma. Talanta 2016, 161: 278-287.

6. Zhihong Wang1, Yaxin Lu1, Kang Qin, Yifan Wu, Yingping Tian, Jianing Wang, Jimin Zhang, Jingli Hou, Yun Cui, Kaiwang, Jie Shen, Qingbo Xu, Deling Kong, Qiang Zhao*, Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug. J Control Release 2015, 210: 179-188.

7. Ping Li, Yiran Fan, Yunlong Wang, Yaxin Lu*, Zheng Yin*, Characterization of plasma protein binding dissociation with online SPE-HPLC. Scientific Reports 2015, 5, 14866.

8. Yiran Fan, Guanghu Shen, Ping Li, Xiaonan Xi, Haiting Wu, Hongjun Tian, Yaxin Lu*, Zheng Yin*, A simple and automated online SPE-LC-MS/MS method for simultaneous determination of olanzapine, fluoxetine and norfluoxetine in human plasma and its application in therapeutic drug monitoring. RSC Adv 2015, 5: 34342–34352.

9. Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Yaxin Lu*, Zheng Yin*, Simultaneous determination of a broad range of cardiovascular drugs in plasma with a simple and efficient extraction/clean up procedure and chromatography– mass spectrometry analysis. RSC Adv 2014, 4: 19629–19639.

10. Lei Liu, Yabin Wen, Kangning Liu, Liang Sun, Meng Wu, Guifang Han, Yaxin Lu*, Qingming Wang*, Zheng Yin*. Optimization of on-line solid phase extraction and HPLC conditions using response surface methodology for determination of WM-5 in mouse plasma and its application to pharmacokinetic study. J Chromatogr B 2013, 923-924: 8-15.

11. Quan Zhang1, Yaxin Lu1, Yahui Ding1, Jiadai Zhai1, Qing Ji, Weiwei Ma, Ming Yang, Hongxia Fan, Jing Long, Bin Han, Wenpeng Zhang, Chuanjiang Qiu, Xiaoyan Ma, Zhongsheng Tong, Yehui Shi, Yongsheng Jia, Qianqian Shi, Haoliang Zhang, Dongmei Li, Jing Zhang, Jianping Lin, Lu-Yuan Li, Yingdai Gao*, Yue Chen*. Guaianolide Sesquiterpene Lactones, a Source to Discover Agents That Selectively Ablate Acute Myelogenous Leukemia Stem and Progenitor Cells. J Med Chem 2012, 55, 8757-8769.

12.Lei Liu, Kangning Liu, Yabin Wen, Hanwen Zhang , Yaxin Lu*, Zheng Yin*. Development of a fully automated on-line solid phase extraction and high-performance liquid chromatography with diode array detection method for the pharmacokinetic evaluation of bavachinin: a study on absolute bioavailability and dose proportionality. J Chromatogr B 2012, 893-894: 21-28.

已毕业硕士研究生2名，协助指导硕士研究生15名，博士研究生3名。