1. 复杂含氮或含氧杂环化合物的高效构建；

2. 基于炔醇或炔胺的串联环化反应新方法研究；

3. 响应性功能聚合物的设计合成及形态与性能研究；

4.功能性高分子智能农药助剂设计合成研究；

1996-2000 武汉市华中师范大学化学系 本科

2001-2007 南开大学元素有机化学研究所 攻读博士研究生

2007-2011 南开大学元素有机化学研究所 讲师

2012-至今 南开大学元素有机化学研究所 副研究员

2014-2015 美国威斯康星大学-麦迪逊分校 访问学者

[1] Hongkai Wang, Tianlong Zeng,Weixing Chang, Lingyan Liu,* and Jing Li*, Au(I)/(R)-BINOL−Ti(IV) Concerted Catalyzed Asymmetric Cascade Cycloaddition Reaction of Arylalkynols, Org. Lett. 2021, 23, 3573−3577. 

[2] Le Zhao, Yong-Guang Jia, Song-Meng Wang, Yi Yang, Ling-Yan Liu,* Wei-Xing Chang, Jing Li*, Controllable polymeric pseudo-crown ether fluorescent sensors: responsiveness and selective detection of metal ion, New. J. Chem. 2021, 45, 2122-2131. 

[3] Jian Jiang, Songmeng Wang, Yuanfang Kong, Wei Yan, Hao Chen, Lingyan Liu,* Weixing Chang, Jing Li,* Well-defined core-shell nanostructural block copolymer supported recyclable Bronsted acidic ionic liquid catalyst for the synthesis of biodiesel, Eur. Polym. J. 2020, 140(5), 109922.

[4] Hongkai Wang, Tianlong Zeng, Xinhong Li, Songmeng Wang, Weiguo Xiao, Lingyan Liu,* Weixing Chang and Jing Li*, Cocatalyst-controlled divergent cascade cycloaddition reaction of arylalkynols and dioxopyrrolidienes: access to spiroketals and oxa-bridged eight-membered cyclic ethers. Org. Chem. Front. 2020, 7, 1809-1816.

[5] Songmeng Wang, Yi Yang, Lingyan Liu*, Weixing Chang, and Jing Li*, A fluorescent polypseudorotaxane formed by cyclopolymer and pyrene ammonium salt for multiple stimuli-responsive, ACS Appl. Polym. Mater. 2020, 2, 2246-2251.

[6] Weilin Wang, Xiaohui Cao, Weiguo Xiao, Xiaoyu Shi, Xiaodan Zuo, Lingyan Liu,* Weixing Chang, Jing Li,* HFIP enables stereodefined hydroamination cyclization of homopropargylic sulfonamides via a hydrogen-bonding cluster and subsequent 2-site modified of pyrrolidines, J. Org. Chem. 2020, 85, 7045-7059.

[7] Xinhong Li, Songmeng Wang, Hongkai Wang, Weilin Wang, Lingyan Liu,* Weixing Chang, Jing Li*, Synthesis of Eight-Membered Nitrogen Heterocycles via a Heterogeneous PtI2-Catalyzed Cascade Cycloaddition Reaction of δ-Aminoalkynes with Electron-Deficient Alkynes, Adv. Synth. Catal. 2020, 362, 1525-1531. 

[8] Xinhong Li, Songmeng Wang, Shengli Li, Kangming Li, Xin Mo, Lingyan Liu*, Weixing Chang, Jing Li*, The hydroamination cyclization [2+2]-cycloaddition cascade reactions of homopropargylic amines with 2-butynedioates: An access to the pyrrolo-b-cyclobutene and dihydro-1H-azepine, J. Org. Chem. 2019, 84, 1288-1298.

[9] Weilin Wang, Yixin Fu, Yimeng Li, Ruitong Yao, Lingyan Liu, * Weixing Chang, Jing Li, Ag(I)-Catalyzed solvent-free CO2 capture with homopropargylic amines: an efficient access to 1,3-oxazinan-2-ones, Org. Chem. Front. 2018, 5, 3331-3335. 

[10] Weilin Wang, Lingyan Liu*, Weixing Chang, Jing Li*, Copper Promoted Regio- and Stereoselective chloroamination of simple alkynes and alkenes with NFSI, Chem. Eur. J. 2018, 24, 8542-8547. 

[11] Qiangqiang Liu, Chan Wang, Lingyan Liu*, Weixing Chang, Jing Li*, The Povarov reaction of cycloiminium formed in situ via hydroamination cycloisomerization of homopropargylic amines with electron-rich olefins, J. Org. Chem. 2017, 82, 950-958. 

[12] Hongkai Wang, Chan Wang, Kaimeng Huang, Lingyan Liu*, Weixing Chang, Jing Li*, Copper catalyzed cascade reaction via intramolecular hydroamination cyclization of homopropargylic amines and intermolecular Povarov reaction with imines Org. Lett. 2016, 18, 2367-2370.

[13] Ming Zhang, Yi Yang, Lingyan Liu*, Weixing Chang, and Jing Li*, Pseudo- Cryptand-Containing Copolymers: Cyclopolymerization and Biocompatible Water-Soluble Al3+ Fluorescent Sensor in Vitro Macromolecules, 2016, 49, 844-852.

[14] Ming Zhang, Lingyan Liu*, Weixing Chang, Jing Li*, Controllable and Reversible Dimple-Shaped Aggregates Induced by Macrocyclic Recognition Effect. Langmuir 2015, 31, 13581-13589. 

[15] Chan Wang, Kaimeng Huang, Junying Wang, Hongkai Wang, Lingyan Liu,* Weixing Chang, and Jing Li Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines via a Sonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence Adv. Synth. Catal. 2015, 357, 2795-2802.

现有1名硕士研究生，已毕业3名硕士研究生。曾经指导本科生百项工程、国创项目等多项，指导本科生毕业论文10余名，并协助指导数十名博士和硕士研究生。