Frustrated Lewis Pairs Catalysis

Asymmetric Catalysis

Transition Metal Catalysis

2003-2007 BS, Nankai University, Tianjin, China. 

2007-2012 PhD, University of Maryland, College Park, Maryland, United States. 

2012-2015 Postdoctoral, The Scripps Research Institute, La Jolla, California, United States.

1. Peng-Xiang Shen, Xiao-Chen Wang, *********, Ru-Yi Zhu, and Jin-Quan Yu* “Ligand-Enabled meta-C–H Alkylation and Arylation Using A Modified Norbornene” J. Am. Chem. Soc., 2015, 137 (36), 11574–11577.

2. Brandon E. Haines, Huiying Xu, Pritha Verma, Xiao-Chen Wang, Jin-Quan Yu*, and Djamaladdin G. Musaev* “Mechanistic Details of Pd(II)-Catalyzed C–H Iodination with Molecular I2: Oxidative Addition vs Electrophilic Cleavage” J. Am. Chem. Soc., 2015, 137 (28), 9022–9031.

3. Xiao-Chen Wang, Wei Gong, Li-Zhen Fang, Ru-Yi Zhu, Suhua Li, Keary M. Engle, and Jin-Quan Yu* “Ligand-Enabled meta-C–H Activation Using a Transient Mediator” Nature, 2015, 519, 334–338.

4. Ru-Yi Zhu, Jian He, Xiao-Chen Wang, and Jin-Quan Yu* “Ligand-Promoted Alkylation of C(sp3)–H and C(sp2)–H Bonds” J. Am. Chem. Soc., 2014, 136 (38), 13194–13197.

5. Xichen Xu, Xiaochen Wang, Yuxiao Liu, Michael P Doyle* “Enantioselective Carbonyl-ene Reactions Catalyzed by Chiral Cationic Dirhodium(II,III) Carboxamidates” J. Org. Chem., 2014, 79 (24), 12185-12190.

6. Ling Chu, Xiao-Chen Wang, Curtis E Moore, Arnold L. Rheingold, and Jin-Quan Yu* “Pd-catalyzed Enantioselective C–H Iodination: Asymmetric Synthesis of Chiral Diarylmethylamines” J. Am. Chem. Soc., 2013, 135 (44), 16344–16347.

7. Xiao-Chen Wang, Yi Hu, Samuel Bonacorsi, Yang Hong, Richard Burrell, and Jin-Quan Yu* “Pd(II)-catalyzed C–H Iodination Using Molecular I2 as the Sole Oxidant” J. Am. Chem. Soc., 2013, 135 (28), 10326–10329. 

8. Yu Qian, Xinfang Xu, Xiaochen Wang, Peter Y. Zavalij, Wenhao Hu and Michael P. Doyle* “Contrasting Results from Rhodium(II) and Copper(II) Catalyzed Reactions of Enoldiazoacetates with Nitrones. Metal Carbene versus Lewis Acid Directed Pathways” Angew. Chem., Int. Ed. 2012, 51 (24), 5900–5903.

9. Xiaochen Wang, Quentin M. Abrahams, Peter Y. Zavalij and Michael P. Doyle* “Highly Regio- and Stereoselective Dirhodium Vinylcarbene-induced Nitrone Cycloaddition with Subsequent Cascade Carbenoid Aromatic Cycloaddition/N-O Cleavage and Rearrangement” Angew. Chem., Int. Ed. 2012, 51 (24), 5907–5910. 

10. Xiaochen Wang, Xinfang Xu, Peter Y. Zavalij and Michael P. Doyle* “Asymmetric Formal [3+3]-Cycloaddition Reactions of Nitrones with Electrophilic Vinylcarbene Intermediates” J. Am. Chem. Soc., 2011, 133 (41), 16402–16405.

11. Xiaochen Wang, Carolin Weigl, and Michael P. Doyle* “Solvent Enhancement of Reaction Selectivity: A Unique Property of Cationic Chiral Dirhodium Carboxamidates” J. Am. Chem. Soc., 2011, 133 (24), 9572–9579.

12. Hong Chen,* Song Zuo, Xiaochen Wang, Xiaowei Tang, Ming Zhao, Yanling Lu, and Liting Chen “Synthesis of 4β-triazole-podophyllotoxin derivatives by azide-alkyne cycloaddition and biological evaluation as potential antitumor agents.” Eur. J. Med. Chem., 2011, 46, 4709-4714.

13. Xiaochen Wang, Zhuoyan Li and Michael P. Doyle* “Barriers to Enantiocontrol in Lewis Acid Catalyzed Hetero-Diels–Alder Reactions” Chem. Commun., 2009, 5612-5614.

14. Jian-Hua Xie, Sheng Liu, Wei-Ling Kong, Wen-Ju Bai, Xiao-Chen Wang, Li-Xin Wang and Qi-Lin Zhou*　“Highly Enantioselective and Diastereoselective Synthesis of Chiral Amino Alcohols by Ruthenium-Catalyzed Asymmetric Hydrogenation of α-Amino Aliphatic Ketones”　J. Am. Chem. Soc., 2009, 131 (12), 4222–4223.