Chemical Biology

Medical Chemistry

Organic Chemistry

2014 Jul. -, Assistant Professor of Chemical Biology, Nankai University.

2010 Oct.-2014 Jun., Postdoctoral Fellow, Johns Hopkins University, Baltimore, MD.

Advisor: Professor Marc M. Greenberg

2004 Oct.- 2010 Sept., Ph.D. in Bioorganic Chemistry, Uppsala University, Sweden.

Thesis Advisor: Professor Jyoti Chattopadhyaya

2001-2004, M. S. in Organic Chemistry, Nankai University, Tianjin, China.

Advisor: Professor Zhen Xi

1997-2001, B.S. in Chemistry, Nankai University, Tianjin, China.

1.F. Guo, Z. Yue, M. Trajkovski, X. Zhou, D. Cao, Q. Li, B. Wang, X. Wen, J. Plavec*, Q. Peng*, Z. Xi and C. Z. Zhou*, Effect of Ribose Conformation on RNA Cleavage via Internal Transesterificatio. J. Am. Chem. Soc., 2018, 140, 11893-11897.

2.Li, F. C.; Zhang, Y. Q.; Bai, J.; Greenberg, M. M.; Xi, Z.; Zhou, C. Z.* 5-Formylcytosine Yields DNA-Protein Crosslinks in Nucleosome Core Particles. J. Am. Chem. Soc. 2017, 139, 10617-10620. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2017, 139, 11629]

3.Zhang, Y. Q.; Zhou, X. P.; Xie, Y. H.; Greenberg, M. M.; Xi, Z. and Zhou, C. Z.* Thiol Specific and Tracelessly Removable Bioconjugation via MichaelAddition to 5?Methylene Pyrrolones. J. Am. Chem. Soc. 2017, 139, 6146?6151. [Recommended by F1000]

4. Zhou, C. Z. and Greenberg, M. M. “DNA Damage by Histone Radicals in Nucleosome Core Particles” J. Am. Chem. Soc. 2014, 136, 6562-6565.

5. Zhou, C.Z., Sczepanski, J. T. and Greenberg, M. M. “Histone modification vis rapid cleavage of C4’-oxidized abasic sites in nucleosome core particles” J. Am. Chem. Soc. 2013, 135, 5274-5277. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2013, 135, 5933]

6. Zhou, C. Z., Sczepanski, J. T. and Greenberg, M. M. “Mechanistic studies on histone catalyzed cleavage of apyrimidinic/apurinic sites in nucleosome core particles” J. Am. Chem. Soc. 2012, 134, 16734-16741.

7. Zhou, C. Z. and Greenberg, M. M. “Histone catalyzed cleavage of nucleosomal DNA containing 2-deoxyrionolactone” J. Am. Chem. Soc. 2012, 134, 8090?8093. [Featured in JACS Spotlights: J. Am. Chem. Soc. 2012, 134, 9021]

8. Zhou, C. Z.and Chattopadhyaya, J. “Intramolecular Free-Radical Cyclization Reactions on Pentose-Sugars for Synthesis of carba-LNA and carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics” Chem. Rev. 2012, 112, 3808-3832.