Synthetic Methodology Development for High Efficient Construction of Natural Product’s Core Structure

1988-1992 B.S., Lanzhou University

1992-1995 M.Sc., Lanzhou University

1997-2001 Ph.D., The University of Hong Kong

2001-2003 Postdoctoral Fellow, Stanford University， USA

2004-now Professor, College of Chemistry, Nankai University 

1.Endo-selective Epoxide-opening Cascade for Fast Assembly of the Polycyclic Core Structure of Marine Ladder Polyethers Feng-Xing Li, Shu-Jian Ren, Pei-Fang Li, Peng Yang, Jin Qu* Angew. Chem. Int. Ed. 2020, 59, ASAP (DOI: 10.1002/anie.202007980)

2.Redox-Neutral α?C?H Functionalization of Pyrrolidin-3-ol Cheng-Bo, Yi, Zhi-Ying, She, Yong-Feng Cheng, Jin Qu* Org. Lett. 2018, 20, 668–671.

3.Molecular Iodine–Mediated ?-C–H Oxidation of Pyrrolidines to N,O-Acetals: Synthesis of (±)-Preussin by Late-Stage 2,5-Difunctionalizations of Pyrrolidine

Hao-Jie, Rong, Jun-Jun, Yao, Ji-Kun, Li, Jin Qu* J. Org. Chem. 2017, 82, 5557–5565.

4.Synthesis of γ-Lactams by Mild, o-Benzoquinone-Induced Oxidation of Pyrrolidines Containing Oxidation-Sensitive Functional Groups Hao-Jie, Rong, Yong-Feng, Cheng, Fan-Fan, Liu, Shu-Jian, Ren, Jin Qu* J. Org. Chem. 2017, 82, 532–540.

5.Ring-Opening/Expansion Rearrangement of Cycloprop[2,3]inden-1-ols Catalyzed by p-Toluenesulfonic Acid Pei-Fang, Li, Cheng-Bo, Yi, Shu-Jian, Ren, Jin Qu* Adv Synth Catal. 2016, 358, 2088–2092

6.Tetraphenylphosphonium Tetrafluoroborate/1,1,1,3,3,3-hexafluoroisopropanol (Ph4PBF4/HFIP) Effecting Epoxide-Initiated Cation-Olefin Polycyclizations Yan Tian, Xin Xu, Lin Zhang, Jin Qu* Org. Lett. 2016, 18, 268–271.

7.Redox-Triggered α-C–H Functionalization of Pyrrolidines: Synthesis of Unsymmetrically 2,5-Disubstituted Pyrrolidines Yong-Feng Hao-Jie Rong, Cheng-Bo Yi, Jun-Jun Yao, and Jin Qu* Org. Lett. 2015, 17, 4758–4761.

8.Hot Water–Promoted Cyclopropylcarbinyl Rearrangement Facilitates Construction of Homoallylic Alcohols; Pei-Fang, Li, Cheng-Bo, Yi, Jin Qu* Org. Biomol. Chem. 2015, 5012?5021.

9.Intramolecular Etherification and Polyene Cyclization of ?-Activated Alcohols Promoted by Hot Water; Feng-Zhi Zhang, Yan Tian, Guo-Xing Li, Jin Qu* J. Org. Chem. 2015, 80, 1107?1115.

10.How Does Aqueous Solubility of Organic Reactants Affect a Water-Promoted Reaction?; Yi-Jie Zuo, Jin Qu* J. Org. Chem. 2014, 79, 6832?6839.

11.Simple and Efficient Synthesis of Tetrahydro-β-Carbolines via the Pictet–Spengler Reaction in 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFIP); Li-Na, Wang, Su-Li, Shen, Jin Qu* RSC Adv. 2014, 4, 30733?30741.

12.1,n-Rearrangement of Allylic Alcohols Promoted by Hot Water: Application to the Synthesis of Navenone B, a Polyene Natural Product; Pei-Fang, Li, Heng-Lu, Wang, Jin Qu* J. Org. Chem. 2014, 79, 3955?3962.

13.A Catalyst-free One Pot Construction of Skeletons of 5-Methoxyseselin and Alloxanthoxyletin in Water; Jin-Li Cao, Su-Li Shen, Peng Yang, Jin Qu* Org. Lett. 2013, 15, 3856–3859.

14.Hot Water-Promoted SN1 Solvolysis Reactions of Allylic and Benzylic Alcohols; Zhao-Bing Xu and Jin Qu* Chem. Eur. J. 2013, 19, 314–323.

15.Two Concise Enantioselective Total Syntheses of (?)-Glabrescol Implicate Alternative Biosynthetic Pathways Starting from Squalene; Peng Yang, Pei-Fang Li, Jin Qu* and Liang-Fu Tang Org. Lett. 2012, 14, 3932–3935.

16.Enantioselective Friedel–Crafts Reaction between Phenols and N-Tosylaldimines Catalyzed by Leucine-Derived Bifunctional Catalyst; Guo-Xing Li and Jin Qu* Chem. Commun. 2012, 48, 5518–5520.

17.Water-Promoted Kinetic Separation of trans- and cis-Limonene Oxides; Zhao-Bing Xu and Jin Qu* Chin. J. Chem. 2012, 1133–1136.

18.Hot water as a mild Br?nsted acid catalyst in ring opening reactions of epoxides; Zhao-Bing Xu and Jin Qu* Science in China Series B 2011, 41, 1468–1476.

19.Backbone Modification of ?-Hairpin-Forming Tetrapeptides in Asymmetric Acyl Transfer Reactions; Peng Chen and Jin Qu* J. Org. Chem. 2011, 76, 2994–3004. (Featured Article)

20.Desymmetrization of meso-1,2-Diols via the Dynamic Kinetic Resolution of Its Monodichloroacetates; Jin-Li Cao and Jin Qu* J. Org. Chem. 2010, 75, 3663–3670.

21.Friedel-Crafts Alkylation of Arenes with Epoxides Promoted by Fluorinated Alcohols or Water; Guo-Xing Li and Jin Qu* Chem. Commun. 2010, 2653–2655.

22.Boiling water-catalyzed neutral and selective N-Boc deprotection; Jia Wang, Yan-Liang Liang and Jin Qu* Chem. Commun. 2009, 5144–5146.

23.Kinetic Resolution of Racemic Alcohols Using Thioamide Modified 1-Methyl-histidine Methyl Ester; Xue-Li Geng, Jia Wang, Guo-Xing Li, Peng Chen, Shu-Fang Tian, and Jin Qu* J. Org. Chem. 2008, 73, 8558–8562.

24.Hot Water Promoted Ring-opening of Epoxides and Aziridines by Water and Other Nucleophiles; Zhi Wang, Yong-Tao Cui, Zhao-Bing Xu, and Jin Qu* J. Org. Chem. 2008, 73, 2270–2274. (Highlighted in Organic Chemistry Portal)