Organic Chemistry, Pesticide Science

Dr. Baolei Wang obtained his Ph.D. degree in pesticide science at Nankai University in 2004 under the supervision of Professor Zhengming Li. Then he stayed in Nankai University working on the basic research of pesticide innovations and teaching for undergraduates. From 2015 to 2016, he served as a visiting scholar at University of Alberta performing research on new organic synthetic methodology under the supervision of Professor Frederick G. West related to cyclic allenes and the Nazarov electrocyclization chemistry. During his working in the Nankai University since 2004, he taught courses of “Organic Chemistry” and “Organic Chemistry Experiments”. His research work mainly focus on the design, synthesis and SAR study of novel organic compounds that have potential biological properties such as herbicidal, insecticidal and fungicidal activities, which target at special enzymes, e.g. ketol-acid reductoisomerase (KARI), for crop protection use. He has chaired and accomplished the research work of some projects supported by the National Natural Science Foundation of China, the National Key Research and Development Program of China, the Specialized Research Fund for the Doctoral Program of Higher Education and Tianjin Natural Science Foundation; has participated in a lot of projects, such as the national “863” and “973” programs, Australia international cooperation project, the National (Key) Natural Science Foundation of China, Tianjin University / Nankai University joint project, and cooperation research projects with Dow Chemical Company and Aberjona Laboratories, Inc.. Currently he is chairing two projects supported by the National Natural Science Foundation of China. He has 60 papers been published and 15 patents been applied. He now is a member of young editorial board of Chinese Chemical Letters, and reviewer of Journal of Agricultural and Food Chemistry, Pest Management Science, Phosphorus Sulfur and Silicon and the Related Elements, Chinese Journal of Organic Chemistry, etc.

Partial papers published listed as follows:

[35] Huan Li, Hang Liu, Yan Zhang, Na Yang, Lixia Xiong, Zhengming Li, Baolei Wang*. Synthesis, insecticidal activities, and SAR studies of novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives. Chin. Chem. Lett., 2021, 32, doi: https://doi.org/10.1016/j.cclet.2021.02.002.

[34] Baolei Wang, Marius-Georgian Constantin, Simarpreet Singh, Yuqiao Zhou, Rebecca L. Davis*, F. G. West*. Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity. Org. Biomol. Chem., 2021, 19: 399-405.

[33] Yan Zhang, Junfeng Shang, Huan Li, Hang Liu, Haibin Song, Baolei Wang*, Zhengming Li*. Synthesis of novel N-pyridylpyrazole derivatives containing 1,2,4-oxadiazole moiety via 1,3-dipolar cycloaddition and their structures and biological activities. Chin. Chem. Lett., 2020, 31: 1276-1280.

[32] Baolei Wang*, Hongxue Wang, Hang Liu, Lixia Xiong, Na Yang, Yan Zhang, Zhengming Li*. Synthesis and structure-insecticidal activity relationship of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety. Chin. Chem. Lett., 2020, 31: 739-745.

[31] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Xiao Zhang, Shu-Jing Yu, Yi Ma, Hai-Bin Song. One-Pot Synthesis, Structure and Structure-Activity Relationship of Novel Bioactive Diphenyl/Diethyl(3-Bromo-1-(3-Chloropyridin-2-yl)-1H-Pyrazol-5-yl)(Arylamino)Methylphosphonates. Pest Manag. Sci., 2019, 75: 3273-3281.

[30] Yan Zhang, Zhengming Li, Haibin Song, Baolei Wang*. Synthesis, Structure and Biological Activities of Novel 2-(Trifluoromethyl)-6- arylimidazo[2,1-b][1,3,4]-thiadiazole (bis-)Mannich Base Derivatives Containing Substitutedpiperazine Moiety. Chin. J. Chem., 2018, 36: 635-638.

[29] Qiao-Xia Liu, Bao-Lei Wang*, Ming-Zhen Mao, Li-Xia Xiong, Zheng-Ming Li. Synthesis and pesticidal activities of novel anthranilic diamides containing pyridylpyrazole and iminodithiocarbamate or thiosemicarbazone motifs. Phosphorus Sulfur Silicon Relat. Elem., 2018, 193(9): 593-599.

[28] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Li-Zhong Wang, Xiao Zhang, Li-Xia Xiong, Hai-Bin Song. Synthesis, Biological Evaluation and SAR Analysis of Novel Poly Heterocyclic Compounds Containing Pyridylpyrazole Group. Pest Manag. Sci., 2018, 74: 726-736.

[27] Bao-Lei Wang*, Li-Yuan Zhang, Xing-Hai Liu, Yi Ma, Yan Zhang, Zheng-Ming Li*, Xiao Zhang. Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2017, 27: 5457-5462.

[26] Bao-Lei Wang*, Yan Zhang, Xing-Hai Liu, Li-Yuan Zhang, Yi-Zhou Zhan, Xiao Zhang, Li-Zhong Wang, Yong-Hong Li, Zheng-Ming Li*. Synthesis and biological activity of novel dimethylpyrazole and piperazine-containing (bis)1,2,4-triazole derivatives. Phosphorus Sulfur Silicon Relat. Elem., 2017: 192, 34-41.

[25] Bao-Lei Wang, Yan-Xia Shi, Shu-*********, Yi Ma, Hong-Xue Wang, Li-Yuan Zhang, Wei Wei, Xing-Hai Liu, Yong-Hong Li, Zheng-Ming Li*, Bao-Ju Li*. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. Eur. J. Med. Chem., 2016, 117: 167-178.

[24] Bao-Lei Wang*, Li-Yuan Zhang, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Li-Zhong Wang, Zheng-Ming Li*. Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties. J. Fluorine Chem., 2016, 184: 36-44.

[23] Yan Zhang, Xing-Hai Liu, Yi-Zhou Zhan, Li-Yuan Zhang, Zheng-Ming Li, Yong-Hong Li, Xiao Zhang, Bao-Lei Wang*. Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2016, 26: 4661-4665.

[22] Bao-Lei Wang*, Yi-Zhou Zhan, Li-Yuan Zhang, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and fungicidal activities of novel 1,2,4-triazole thione derivatives containing 1,2,3-triazole and substituted piperazine moieties. Phosphorus Sulfur Silicon Relat. Elem., 2016, 191: 48-54.

[21] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives. Chin. Chem. Lett., 2016, 27: 163-167.

[20] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Xue-Wen Hua, Ming Liu, Xiao Zhang, Hai-Bin Song, Zheng-Ming Li*. Synthesis and biological activity of novel N-glucosides containing substituted piperazine moiety. Lett. Drug Des. Discov., 2016, 13 (4): 343-351.

[19] Yizhou Zhan, Baolei Wang*, Liyuan Zhang, Yan Zhang, Xiao Zhang, Zhengming Li*, Haibin Song. Studies on the Synthesis, Structure and Biological Activities of Novel Arylaminoformyl-containing 1-Cyano-1-cycloproane Carboxylic Acid Amides Based on Ugi Reaction. Acta Chim. Sinica, 2015, 73, 1173-1181.

[18] Baolei Wang, Yanxia Shi, Yizhou Zhan, Liyuan Zhang, Yan Zhang, Lizhong Wang, Xiao Zhang, Yonghong Li, Zhengming Li*, Baoju Li*. Synthesis and Biological Activity of Novel Furan/Thiophene and Piperazine-Containing (Bis)1,2,4-triazole Mannich Bases. Chin. J. Chem., 2015, 33(10): 1124-1134.

[17] Bao-Lei Wang*, Jing Wu, Qiao-Xia Liu, Yong-Hong Li, Hai-Bin Song, Zheng-Ming Li*. Synthesis, structure, and biological activities of [5-(arylthio/sulfinyl/sulfonyl)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2015, 190(1): 66-78.

[16] Bao-Lei Wang*, Qing-Nan Li, Yi-Zhou Zhan, Li-Xia Xiong, Shu-Jing Yu, Zheng-Ming Li*. The synthesis and biological activities of [5-(4-substituted phenylsulfinyl/sulfonyl)-1,3-dimethyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2014, 189: 483-491.

[15] Bao-Lei Wang, Hong-Wei Zhu, Yi Ma, Li-Xia Xiong, Yong-Qiang Li, Yu Zhao, Ji-Feng Zhang, You-Wei Chen, Sha Zhou, Zheng-Ming Li*. Synthesis, Insecticidal Activities, and SAR Studies of Novel Pyridylpyrazole Acid Derivatives Based on Amide Bridge Modification of Anthranilic Diamide Insecticides. J. Agric. Food Chem., 2013, 61: 5483-5493.

[14] Zhang, Ji-Feng ; Liu, Chen; Ma, Yi; Wang, Bao-Lei*; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming*. Synthesis of Novel 3-Chloropyridin-2-yl-Pyrazole Derivatives and their Insecticidal, Fungicidal Activities and QSAR Study. Lett. Drug Des. Discov., 2013, 10(6): 497-506.

[13] Wang Baolei, Ma Yi, Xiong Lixia, Li Zhengming. Synthesis and Insecticidal Activity of Novel N-Pyridylpyrazole Carbonyl Thioureas. Chin. J. Chem., 2012, 30: 815-821.

[12] Ji-Feng Zhang, Jun-Ying Xu, Bao-Lei Wang, Yu-Xin Li, Li-Xia Xiong, Yong-Qiang Li, Yi Ma, Zheng-Ming Li. Synthesis and Insecticidal Activities of Novel Anthranilic Diamides Containing Acylthiourea and Acylurea. J. Agric. Food Chem., 2012, 60: 7565-7572.

[11] Wang Bao-Lei, Liu Xing-Hai, Zhang Xiu-Lan, Zhang Ji-Feng, Song Hai-Bin, Li Zheng-Ming*. Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety. Chem. Biol. Drug Des., 2011, 78: 42-49.

[10] Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju*; Li, Zheng-Ming*. Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. J. Agric. Food Chem., 2010, 58(9): 5515-5522.

[9] Wang, B. L.; Ma, R. D.; Li, Y. H.; Song, H. B.; Li, Z. M. Synthesis, Structure and Biological Activity of 2- 4-(5-Substituted-1,3,4-oxadiazol-2-yl)phenoxy Propanoate/Acetate. Chin. J. Org. Chem., 2010, 30(1): 92-97. 

[8] Wang, B. L.; Liu, X. H.; Li, Z. M., Synthesis and Characterization of O,O-Dimethyl-N-(2,2,2-trichloro- 1-arylaminoethyl) Phosphoramidothioates. Phosphorus Sulfur Silicon Relat. Elem., 2009, 184(9): 2281-2287. 

[7] Bao-Lei Wang, Yong-Hong Li, Jian-Guo Wang, Yi Ma, Zheng-Ming Li. Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors. Chin. Chem. Lett., 2008, 19: 651-654.

[6] WANG Bao-Lei, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Synthesis and Herbicidal Activities of 4-Alkoxy/benzyloxyphenyltetrazoles and 1,3,4-Oxadiazoles. Chem. J. Chin. U., 2008, 29(1): 90-94.

[5] Bao-Lei Wang, Zheng-Ming Li, Yong-Hong Li, Su-********. Syntheses and biological activities of ethyl N-hydroxy-N-(substituted)phenyloxamates as KARI inhibitors. Chem. Res. Chin. U., 2007, 23(3): 280-283.

[4] Bao-Lei Wang, Ronald G Duggleby, Zheng-Ming Li, Jian-Guo Wang, Yong-Hong Li, Su-********, Hai-Bin Song. Synthesis, crystal structure and hebricidal activity of mimics of intermediates of the KARI reaction. Pest Manag. Sci., 2005, 61: 407-412.

[3] WANG Bao-Lei, WANG Jian-Guo, MA Yi, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Molecular Docking and 3D-QSAR Research of Amidines of KARI Inhibitor. Acta Chimica Sinica, 2006, 64(13): 1373-1378.

[2] WANG Bao-Lei, LI Zheng-Ming, MA Yi, WANG Jian-Guo, LUO Xiao-Min, ZUO Zhi-Li. 3D-Database Searching Based on the Crystal Structure of Ketol-acid Reductoisomerase (KARI) Complex. Chin. J. Org. Chem., 2004, 24(8): 973-976.

[1] Wang Bao-Lei, Ma Ning, Wang Jian-Guo, Ma Yi, Li Zheng-Ming, Li Yong-Hong. 3D-QSAR Analysis of New Sulfonylureas Related to Their Herbicidal Activity. Acta Physico-chimica Sinica, 2004, 20(6): 577-581.

Partial authorized patents listed as follows:

[5] Mannich base type derivative of 1,2,4-triazole cyclo[4,3-a] fused piperazine and preparation method and application thereof. Faming Zhuanli Shenqing (2017), CN 106749262 A, 20170531.

[4] Preparation of triazole Mannich alkali compounds as agricultural pesticide and herbicide. Faming Zhuanli Shenqing (2015), CN 105111192 A, 20151202.

[3] Preparation of 1,2,4-trizole thioketone derivative containing (hetero)aryl and piperazine and their application as the antibacterial agents in agriculture field. Faming Zhuanli Shenqing (2016), CN 105330651 A, 20160217.

[2] Piperazine-containing 1,3,4-oxadiazole Mannich base compound as keto-acid reductoisomerase (KARI) inhibitor for prevention and treatment of weed and fungi attack on crops and its preparation. Faming Zhuanli Shenqing (2016), CN 105541748 A, 20160504.

[1] Preparation of N-aminothioxomethyl pyrazolecarboxamide derivatives as agricultural pesticides. Faming Zhuanli Shenqing (2011), CN 102276580 A, 20111214.