Liu Dingbin, Doctor degree, Researcher, Research Center of Analytical Science,graduated from Chinese Academy of Sciences

Special Talent：

1.Cancer biomarker screening by advanced separation and enrichment techniques

2.Development of highly sensitive and specific molecular imaging probes

3.Establishment of new in vitro diagnostic methods for clinical translation

2002-2006 Lanzhou University(BS)

2006-2009 Chengdu Institute of Biology, CAS(MS)

2009-2012 National Center for Nanoscience and Technology(PhD)

2012-2014 National Institutes of Health(NRC NIH-NIST Postdoc Fellow)

2014-present Nankai University(Professor)

The development of high-performance analytical methods is key to biomedical analysis and clinical diagnosis. It remains a formidable challenge to extract target signals from complex biological systems. In recent years, my research work focuses on the recording of weak target signals from complex biological systems. To do this, we proposed two new strategies, including (1) using exogenous groups (e.g., nitrile and alkyne groups) for background-free Raman analysis to eliminate the possible interference of biological background signals, so as to improve the signal-to-background ratio of complex system analysis; (2) proposing stimulus-response probes to improve the specificity and stability of the probe in complex systems. Besides, we developed a set of colloidal gold nanoparticle-based immunoassays for the rapid diagnosis of major diseases, such as cancers. In the past few years, we are interested in the labeling and detection of extracellular vesicles due to their essential roles in disease diagnosis.

Our research interests mainly include: 1) background-free Raman spectroscopy, 2) stimulus-responsive biosensing system, 3) high-sensitivity assays for rapid analysis, and 4) labeling and analysis of extracellular vesicles.

Peer-reviewed publications since 2014：

(1) Cai Zhang, Xiaoyu Cui, Jie Yang, Xueguang Shao, Yuying Zhang, Dingbin Liu*. Stimulus-responsive surface-enhanced Raman scattering: a “Trojan horse” strategy for precision molecular diagnosis of cancer. Chemical Science, 2020, DOI: 10.1039/D0SC01649G (Front Cover).

(2) Cai Zhang, Zhiwen Xu, Huixia Di, Erzao, Zeng, Ying Jiang, Dingbin Liu*. Gadolinium-Doped Prussian Blue Nanoparticle as a Theranostic Agent for Dendritic Cell Activating and Tracking. Theranostics, 2020, 10, 6061-6071.

(3) Ying Jiang, Lei Wang, Pengjuan Zhang, Xuehui Liu, Huixia Di, Jie Yang, Shu-Lin Liu, Dai-Wen Pang, Dingbin Liu*. Chemoenzymatic Labeling of Extracellular Vesicles for Visualizing Their Cellular Internalization in Real Time. Analytical Chemistry 2020, 92, 2103-2111.

(4) Qiang Li, Fengchao Wang, Jie Yang,* Dingbin Liu*. Direct cytoplasm delivery of gold nanoparticles for real-time apoptosis detection. Nano Research, 2020, 13, 853-860.

(5) Shuxin Song, Jingyu Wang, Na Song, Huixia Di, Dingbin Liu, Zhilin Yu*. Peptide interdigitation-induced twisted nanoribbons as chiral scaffolds for supramolecular nanozymes. Nanoscale, 2020, 12, 2422-2433.

(6) Wenshuai Li, Guorui Wu, Xijing Zhang, Aiqin Yue, Weijun Du, Jinzhong Zhao,* Dingbin Liu* Advances in Bacterial Detection Based on Raman Spectroscopy. Chemical Journal of Chinese Universities, 2020, 41, 872-883.

(7) Bo Dong, Shuangli Du, Chunxiao Wang, Haohao Fu, Qiang Li, Nannan Xiao, Jie Yang, Xue Xue, Weisheng Cai, Dingbin Liu*. Reversible Self-Assembly of Nanoprobes in Live Cells for Dynamic Intracellular pH Imaging. ACS Nano, 2019, 13, 1421-1432.

(8) Pengjuan Zhang, Haohao Fu, Shuangli Du, Fengchao Wang, Jie Yang, Wensheng Cai,* Dingbin Liu*. Click-RNA for Rapid Capture and Identification of Intracellular MicroRNA Targets. Analytical Chemistry, 2019, 91, 15740-15747.

(9) Xuehui Liu, Xiaoman Liu, Pengfei Rong,* Dingbin Liu*, Recent Advances in Background-Free Raman Scattering for Bioanalysis. Trends in Analytical Chemistry, 2019, 123, 115765.

(10) Qiang Li, Xinkai Qiao, Fengchao Wang, Xuejing Li, ********, Linqi Shi, Dingbin Liu*. Encapsulating a Single Nanoprobe in a Multifunctional Nanogel for High-Fidelity Imaging of Caspase Activity in Vivo. Analytical Chemistry, 2019, 91, 13633-13638.

(11) Huixia Di, Erzao Zeng, Pengjuan Zhang, Xuehui Liu, Cai Zhang, Jie Yang, Dingbin Liu*. General Approach to Engineering Extracellular Vesicles for Biomedical Analysis. Analytical Chemistry, 2019, 91, 12752-12759.

(12) Ji Qi, Jun Li, Ruihua Liu, Qiang Li, Haoke Zhang, Jacky W. Y. Lam, Tyan T. k. Kwok, Dingbin Liu, Dan Ding* and Benzhong Tang*. Boosting Fluorescence-Photoacoustic-Raman Properties in One Fluorophore for Precise Cancer Surgery. Chem, 2019, 5, 2657-2677.

(13) Xuejing Li, Erzao Zeng, Huixia Di, Qiang Li, Jingwei Ji, Jie Yang*, Dingbin Liu*. When Prussian Blue Meets Porous Gold Nanoparticles: A High Signal-to-Background Surface-Enhanced Raman Scattering Probe for Cellular Biomarker Imaging. Advanced Biosystems, 2019, 3, 1900046.

(14) Yang Deng, Dianqi Li, Xingming Ning, Dongxu Zhang, Shouting Zhang, Zhen Zhang, Duoliang Shan, Zhenyu Wang, Dingbin Liu, Xiang Mao*, Xiaoquan Lu*. Self-Assembly of Biocompatible FeSe Hollow Nanostructures and 2D CuFeSe Nanosheets with One- and Two-Photon Luminescence Properties. Small, 2019, 15, 1900627.

(15) Dianqi Li, Fengchao Wang, Huixia Di, Xuehui Liu, Pengjuan Zhang, Wen Zhou, Dingbin Liu*. Cross-Linked Polyethylene Glycol Shells for Nanoparticles: Enhanced Stealth Effect and Colloidal Stability. Langmuir, 2019, 35, 8799-8805.

(16) Yang Xue, Bo Dong, Xuehui Liu, Fengchao Wang, Jie Yang, Dingbin Liu*. Using Selenium-conjugated Polyethylene Glycol to Enhance the Stability of Gold Nanoparticles in Biologically Relevant Samples. Science China Chemistry, 2019, 62, 280-286.

(17) Penguan Zhang, Jie Yang,* Dingbin Liu*. Two-step Signal Amplification for High-Sensitivity Detection of Biomarkers using Gold Nanoparticle-based Conjugates. Electrophoresis, 2019, 40, 2211-2217.

(18) Mingmin Li, Jianzhen Wu, Mengtian Ma, Zhichao Feng, Ze Mi, Pengfei Rong,* Dingbin Liu*. Alkyne- and Nitrile-Anchored Gold Nanoparticles for Multiplex SERS Imaging of Biomarkers in Cancer Cells and Tissues. Nanotheranostics, 2019, 3, 113-119.

(19) Fengchao Wang, Qiang Li, Penguan Zhang, Xuehui Liu, Ang Li, Jie Yang, Dingbin Liu*. Assembly of DNA Probes into Superstructures for Dramatically Enhancing Enzymatic Stability and Signal-to-Background Ratio. ACS Sensors, 2018, 3, 2702-2708.

(20) Penguan Zhang, Bo Dong, Erzao Zeng, Fengchao Wang, Ying Jiang, Dianqi Li, Dingbin Liu*. In Vivo Tracking of Multiple Tumor Exosomes Labeled by Phospholipid-Based Bioorthogonal Conjugation. Analytical Chemistry, 2018, 90, 11273-11279.

(21) Xia Gao, Qiang Li, Fengchao Wang, Xuehui Liu, Dingbin Liu*. Dual-Responsive Self-Assembled Monolayer for Specific Capture and On-Demand Release of Live Cells. Langmuir, 2018, 34, 8145-8153.

(22) Jin Li, Huiqiao Liu, Pengfei Rong, Wen Zhou, **********, Dingbin Liu*. A Universal ******** for One-pot Synthesis of SERS Tags. Nanoscale, 2018, 10, 8292-8297.

(23) Wen Zhou, Qiang Li, Huiqiao Liu, Jie Yang, Dingbin Liu*. Building Electromagnetic Hot Spots in Living Cells via Target-Triggered Nanoparticle Dimerization. ACS Nano, 2017, 11, 3532-3541.

(24) Sisi Ma, Qiang Li, Yongmei Yin, Jie Yang, Dingbin Liu*. Interference-Free Surface‐Enhanced Raman Scattering Tags for Single‐Cell Molecular Imaging with a High Signal‐to‐Background Ratio. Small, 2017, 13, 1603340.

(25) Huixia Di, Huiqiao Liu, Mingmin Li, Jin Li, Dingbin Liu*. High-Precision Profiling of Sialic Acid Expression in Cancer Cells and Tissues Using Background-Free SERS Tags. Analytical Chemistry, 2017, 89, 5874-5881.

(26) Huiqiao Liu, Qiang Li, Mingmin Li, Sisi Ma, Dingbin Liu*. In-Situ Hot-Spot Assembly as a General ******** for Probing Single Biomolecules. Analytical Chemistry, 2017, 89, 4776-4780.

(27) Mingmin Li, Jin Li, Huixia Di, Huiqiao Liu, Dingbin Liu*. Live-Cell Pyrophosphate Imaging by In-Situ Hot-Spot Generation. Analytical Chemistry, 2017, 89, 3532-3537.

(28) Dingbin Liu*, Xiaoyuan Chen*. An Ultrasensitive Biosensing Platform Employing Acetylcholinesterase and Gold Nanoparticles. Cancer Nanotechnology: Methods and Protocols, 2017: 307-316.

(29) Yongmei Yin, Qiang Li, Sisi Ma, Huiqiao Liu, Bo Dong, Jie Yang, Dingbin Liu*. Prussian Blue as a Highly Sensitive and Background-Free Resonant Raman Reporter. Analytical Chemistry, 2017, 89, 1551-1557.

(30) Yanmei Xiong, Mingmin Li, Huiqiao Liu, Zhihong Xuan, Jie Yang*, Dingbin Liu*. Janus PEGylated Gold Nanoparticle: A Robust Colorimetric Probe for Sensing Nitrite Ions in Complex Samples. Nanoscale, 2017, 9, 1811-1815.

(31) Yuyan Zhang, Wen Zhou, Yang Xue, Jie Yang, Dingbin Liu*. Multiplexed Imaging of Trace Residues in a Single Latent Fingerprint. Analytical Chemistry, 2016, 88, 12502-12507.

(32) Zhihong Xuan, Mingmin Li, Pengfei Rong, Wei Wang, Yijun Li*, Dingbin Liu*. Plasmonic ELISA based on the controlled growth of silver nanoparticles. Nanoscale, 2016, 8, 17271-17277.

(33) Fangfei Yin, Huiqiao Liu, Qiang Li, Xia Gao, Yongmei Yin, Dingbin Liu*. Trace MicroRNA Quantification by Means of Plasmon-Enhanced Hybridization Chain Reaction. Analytical Chemistry, 2016, 88, 4600-4604.

(34) Huiqiao Liu, Pengfei Rong, Hongwei Jia, Jie Yang, Bo Dong, Qiong Dong, Cejun Yang, Pengzhi Hu, Wei Wang, Haitao Liu, Dingbin Liu*, Wash-Free Homogeneous Colorimetric Immunoassay Method. Theranostics, 2016, 6, 54-64.

(35) Wen Zhou, Xia Gao, Dingbin Liu*, and Xiaoyuan Chen*, Gold nanoparticles for in vitro diagnostics. Chemical Reviews, 2015, 115, 10575-10636.

(36) Shouju Wang , Zhaogang Teng, Peng Huang, Dingbin Liu, Ying Liu, Ying Tian, Jing Sun, Yanjun Li, Huangxian Ju, Xiaoyuan Chen, and Guangming Lu*. Reversibly Extracellular pH Controlled Cellular Uptake and Photothermal Therapy by PEGylated Mixed‐Charge Gold Nanostars. Small, 2015, 11, 1801-1810.

(37) Yanmei Xiong, Yuyan Zhang, Pengfei Rong, Jie Yang, Wei Wang, Dingbin Liu*, A high-throughput colorimetric assay for glucose detection based on glucose oxidase-catalyzed enlargement of gold nanoparticles. Nanoscale, 2015, 7, 15584-15588.

(38) Dingbin Liu*, Jie Yang, He-Fang Wang, Zhongliang Wang*, Xinglu Huang, Zhantong Wang, Gang Niu, A. R. Hight Walker, and Xiaoyuan Chen*, Glucose Oxidase-Catalyzed Growth of Gold Nanoparticles Enables Quantitative Detection of Attomolar Cancer Biomarkers. Analytical Chemistry, 2014, 86, 5800-5806.