2005-2009 B.S. in Chemistry, Zhengzhou University

2009-2014 Ph.D. in Organic Chemistry, Shanghai Institute of Organic chemistry, CAS. (Supervisor: Yong Tang & Zuowei Xie)

2014-2018 Postdoc, UTSouthwestern Medical Center (with Prof. Daniel J. Siegwart)

2008.12- Professor, Research Center for Analytical Science, Nankai University

Selected publications：

(15) Xiong, H.*, Liu, S., Wei, T., Cheng, Q., Siegwart, D. J.* Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. Journal of Controlled Release, 2020, Accepted.

(14) Xiong, H., Zhou, K., Yan, Y., Miller, J. B., Siegwart, D. J.* Tumor activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy. ACS Applied Materials & Interfaces, 2018, 10, 16335-16343.

(13) Yan, Y., Xiong, H., Zhang, X., Cheng, Q., Siegwart, D. J.* Systemic mRNA delivery to the lungs by functional polyester-based carriers. Biomacromolecules, 2017, 18, 4307-4315.

(12) Xiong, H., Zuo, H., Yan, Y., Occhialini, G., Zhou, K., Wan, Y., Siegwart, D. J.* High-contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastases via size-controlled pH-activatable water-soluble probes. Advanced Materials, 2017, 29, 1700131.

(11) Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., Siegwart, D. J.* Non-viral CRISPR/Cas gene editing in vitro and in vivo enabled by synthetic nanoparticle co-delivery of Cas9 mRNA and sgRNA. Angew. Chem. Int. Ed. 2017, 56, 1059-1063.

(10) Feng, L.-W., Ren, H., Xiong, H., Wang, P., Wang, L., Tang, Y.* Reaction of Donor-Acceptor Cyclobutanes with Indoles: A General Protocol for the Formal Total Synthesis of (±)-Strychnine and the Total Synthesis of (±)-Akuammicine. Angew. Chem. Int. Ed. 2017, 129, 3101-3104.

(9) Chen, P., Zuo, H., Xiong, H., Kolar, M. J., Chu, Q., Saghatelian, A., Siegwart, D. J., Wan, Y.* Gpr132 Sensing of Lactate Mediates Tumor-Macrophage Interplay to Promote Breast Cancer Metastasis. Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 580-585.

(8) Yan, Y., Zhou, K., Xiong, H., Miller, J. B., Motea, E. A., Boothman, D. A., Liu, L.*, Siegwart, D. J.* Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors. Biomaterials, 2017, 118, 84-93.

(7) Yan, Y., Liu, L., Xiong, H., Miller, J. B., Zhou, K., Kos, P., Huffman, K. E., Elkassih, S., Norman, J. W., Carstens, R., Kim, J., Minna, J. D., Siegwart, D. J.* Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 5702-5710.

(6) Xiong, H., Kos, P., Yan, Y., Zhou, K., Miller, J. B., Elkassih, S., Siegwart, D. J.* Activatable water-soluble probes enhance tumor imaging by responding to dysregulated pH and exhibiting high tumor-to-liver fluorescence emission contrast. Bioconjugate Chemistry, 2016, 27, 1737-1744.

(5) Zhou, K., Nguyen, L. H., Miller, J. B., Yan, Y., Kos, P., Xiong, H., Li, L., Hao, J., Minnig, J. T., Zhu, H., Siegwart, D. J.* Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 520-525.

(4) Hao, J., Kos, P., Zhou, K., Miller, J. B., Xue, L., Yan, Y., Xiong, H., Elkassih, S., Siegwart, D. J.* Rapid synthesis of a lipocationic polyester library via ring-opening polymerization of functional valerolactones for efficacious siRNA delivery. J. Am. Chem. Soc. 2015, 137, 9206-9209.

(3) Xiong, H., Xu, H., Liao, S., Xie, Z.*, Tang, Y.* Copper-Catalyzed Highly Enantioselective Cyclopentannulation of Indoles with Donor-Acceptor Cyclopropanes. J. Am. Chem. Soc. 2013, 135, 7851-7854. (Highlighted in SYNFORM 2013, 10, 122.)

(2) Xu, H., Qu, J.-P., Liao, S., Xiong, H., Tang, Y.* Highly Enantioselective [3+2] Annulation of Cyclic Enol Silyl Ethers with Donor–Acceptor Cyclopropanes: Accessing 3a-Hydroxy [n.3.0] Carbobicycles. Angew. Chem. Int. Ed. 2013, 52, 4004-4007.

(1) Li, J., Liao, S.-H., Xiong, H., Zhou, Y.-Y., Sun, X.-L., Zhang, Y., Zhou, X.-G., Tang, Y.* Highly Diastereo- and Enantioselective Cyclopropanation of 1,2-Disubstituted Alkenes. Angew. Chem. Int. Ed. 2012, 51, 8838-8841.