Research Highlights - 影像南开

Clinical trials of ACT001, a New Drug Candidate originally developed

Prof. Yue Chen invented an anti-glioblastoma drug candidate ACT001, which can penetrate the blood-brain barrier and selectively kill cancer stem cells. Ten clinical trials have been approved in China, America and Australia. At present, phase I clinical trials in China and Australia have been completed, and six phase 1b / 2a and phase II clinical trials are ongoing. Also, it was designated as orphan drug by FDA and EMA. In 2018, part of the outcome of phase I was presented in ASCO meeting.

Synthesis and Biology of Complex Peptides and Carbohydrates

Prof. Gong Chen’s research is focused on complex peptides and carbohydrates. His group developed new synthetic methodologies based on metal-catalyzed and radical-mediated “C-H” functionalization chemistry for synthesis and modification of amino acids, and applied the methods to total synthesis of complex peptide natural products. His group is particularly interested in syntheses and biological activities of cyclic peptides. They also study the biological functions of special N-linked oligosacc

Nonstoichiometric Electrode Materials Chemistry

Prof. Fangyi Cheng’s research interests focus on electrode materials for electrochemical energy conversion and storage. He proposed new mild strategies for selective preparation of a series of spinel and perovskite-type 3d metal oxides with tunable shape, size, oxygen deficiency and metal valence. He elucidated the effect of nonstoichiometry on enhancing the electrocatalytic oxygen reduction/evolution activity and ion-intercalation performance. By applying oxygen-vacant and cation-defective sp

Fluorine chemistry

Prof. Pingping Tang’s research is focused on the late-stage functionalization methods and the total synthesis of natural products for new drug development. His group is interested in the practical total synthesis of natural products for which there is a true impetus for their construction due to potential pharmaceutical applications. Another major focus of his research is the late-stage functionalization methods, such as late-stage trifluoromethoxylation of organic molecules, yet methods capab

Micro-nano Structured Metal Based Energy Materials

Prof. Lifang Jiao’s research interests focus on the application of metal-based energy materials with micro-nano structure in electrochemical energy storage and electrocatalytic energy conversion. Her researches aim to realize the application of renewable energy. Key electrode materials for electrochemical storage of alkali metal ions with high performance have been designed, synthesized, and the electrochemical reaction mechanism been revealed. A serials of cheap electrocatalytic catalyst for

Organic solar cell

Prof. Xiangjian Wan’s research interests focus on organic functional material design and application, especially on active material design and device optimization of organic solar cells (OSCs). He has designed and synthesized a series of active materials including donor and acceptor molecules for application in OSCs. High efficiency single and tandem organic photovoltaic devices have been successfully fabricated using those materials.