姓名：车永哲
职称：教授

一、教育经历
1978.9-1983.6 延边大学医学院学士毕业
1986.9-1989.6 延边大学医学院硕士毕业
1996.2-1999.2 韩国仁荷大学医科大学博士毕业

二、工作经历
1983.7 - 1986.8 东北内蒙古煤炭公司珲春矿区职工医院外科医师
1988.12 - 2001.10 延边大学医学院解剖学教研室讲师
1999.3- 2001.7 韩国仁荷大学博士后研究员
2001.11-2011.11南开大学医学院副教授，硕士生导师
2011.12- 南开大学医学院教授
2004.3- 至今教育部生物活性材料重点实验室成员

三、研究方向（包括承担课题项目）
1. 脑缺血与神经细胞再生
2. 脑缺血与神经胶质细胞的生物学
3. 心肌梗死干细胞及基因治疗
4. 组织工程与再生医学

承担课题项目：
1. 肠新免疫识别受体LRRC19介导的特异性免疫在肠炎癌发生发展过程中的作用（91442111）重大研究计划，2015.1-2017-12，参与
2. 肿瘤与非肿瘤环境中表观遗传修饰对髓系抑制细胞极化的调控作用（31461143010）国际合作与交流项目，2014.10-2017.9，参与
3. 银屑病新药开发与评价（横向）2015-2018
4. 干细胞分化表观遗传调控及其治疗糖尿病应用基础研究，科技部国家重大研究计划（编号2011CB964902），2011.1-2015.12
5. 肿瘤发生和发展过程中髓系免疫抑制细胞的信号网络及其表观遗传调控，国家自然基金重大研究计划（91029736），2011.1-2013.12

四、学术兼职
1中国解剖学学会会员
2. 天津解剖学会理事
3. 天津市生物医学工程学会会员

五、近5年发表论文
1. Feng G, Zhang J, Li Y, Nie Y, Zhu D, Wang R, Liu J, Gao J, Liu N, He N, Du W, Tao H, Che Y, Xu Y, Kong D, Zhao Q, Li Z.IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI.ASN ASN.2015050578; published ahead of print February 11, 2016
2. Cao S, Su X, Zeng B, Yan H, Huang Y, Wang E, Yun H, Zhang Y, Liu F, Li W, Wei H, Che Y, Yang R. The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation. Cell Rep. 2016 Feb 2; 14(4): 695–707.
3. Su X, Yan H, Huang Y, Yun H, Zeng B, Wang E, Liu Y, Zhang Y, Liu F, Che Y, Zhang Z, Yang R. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep. 2015 21;5:18588.
4. Zhao Q, Che Y, Li Q, Zhang S, Gao YT, Wang Y, Wang X, Xi W, Zuo W, Li SJ. The voltage-gated proton channel Hv1 is expressed in pancreatic islet β-cells and regulates insulin secretion. Biochem Biophys Res Commun. 2015 25;468(4):746-51.
5. Ke T. Yang M. Mao D. Zhu M. Che Y. Kong D. Li C. Co-Transplantation of Skin-Derived Precursors and Collagen Sponge Facilitates Diabetic Wound Healing by Promoting Local Vascular Regeneration. Cell Physiol Biochem 2015;37:1725-1737
6. Mao D, Yao X, Feng G, Yang X, Mao L, Wang X, Ke T, Che Y, Kong D.Skin-derived precursor cells promote angiogenesis and stimulate proliferation of endogenous neural stem cells after cerebral infarction.Biomed Res Int. 2015;Epub 2015 Mar 26.
7. xiaomin Su, Siping Min, shuisong cao, hui yian, yining zhao, hui li, Limin Chai, shiyue mei, jia yang, yuan zhang, Zhujun Zhang, Feifei Liu, Wei sun, yongzhe che, and Rongcun Yang. LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. Nature Communications 2014 Jul 16; 10.1038/ncomms5434.
8. 李晔，包旭，陈曦，郏欣茹，许松山，车永哲. 小鼠毛囊再生与胸腺素beta4的促进效应. 中国组织工程研究, 2014,18(11):1687-1693.
9. Su X, Mei S, Liang X, Wang S, Liu J, Zhang Y, Bao Y, Chen Y, Che Y, Chunhua Zhao R, Zhang Z, Yang R.Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors.J Leukoc Biol. 2014 96(1):17-26
10. Feng G, Mao D, Che Y, Su W, Wang Y, Xu Y, Fan Y, Zhao H, Kong D, Xu Y, Li Z.The phenotypic fate of bone marrow-derived stem cells in acute kidney injury.Cell Physiol Biochem. 2013;32(5):1517-27.
11. Jingyi Liu,Zhujun Zhang, Limin Chai, Yongzhe Che, Siping Min, Rongcun YangIdentification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation. Biochem Biophys Res Commun 2013,434(1):28-34
12. Min S, Liang X, Zhang M, Zhang Y, Mei S, Liu J, Liu J, Su X, Cao S, Zhong X, Li Y, Sun J, Liu Q, Jiang X, Che Y, Yang R.Multiple Tumor-Associated MicroRNAs Modulate the Survival and Longevity of Dendritic Cells by Targeting YWHAZ and Bcl2 Signaling Pathways.J Immunol. 2013 190(5):2437-2447
13. Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D.Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction.Cardiovasc Res. 2013 ;97(2):208-18.
14. Jia X, Xie X, Feng G, Lű H, Zhao Q, Che Y, Zheng Y, Han Z, Xu Y, Li Z, Kong D.Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury.BMC Nephrol. 2012 ;13:105.
15. Wang K, Guan Y, Liu Y, Zhu M, Li T, An D, Ou L, Che Y, Zhang G, Zhang J, Zheng XL, Kong D.Fibrin glue with autogenic bone marrow mesenchymal stem cells for urethral injury repair in rabbit model.Tissue Eng Part A. 2012 ,18(23-24):2507-2517.
16. Clinicopathological and biological significance of human voltage-gated proton channel Hv1 over-expression in breast cancer. Wang Yifan, Li Shujie, Wu Xiang, Che Yongzhe, Li Qiang. J Biol Chem. 2012, 2,24通讯作者
17. Preparation and evaluation of magnetic nanoparticles for cell labeling.Wang Y, Wang Y, Wang L, Che Y, Li Z, Kong D.J Nanosci Nanotechnol. 2011，11(5):3749-56.
18. Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis.Wang Y, Li SJ, Pan J, Che Y, Yin J, Zhao Q.Biochem Biophys Res Commun. 2011 26;412(2):353-359.
19. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion.Liu X, Duan B, Cheng Z, Jia X, Mao L, Fu H, Che Y, Ou L, Liu L, Kong D. Protein cell，2011,2（10）：845-854
20. Improved neuronal survival of focal ischemia after delipid extracorporeal lipoprotein (DELP) treatment in hyperlipidemic rabbits. Liu G, Wang W, Xie H, Che Y, Xue J, Wu Y, Zhou Q, Kong D.Artificial organs 2011，35（7）：E145-154通讯作者
21. 胸腺素β4对急性心肌梗死大鼠心肌磷酸化蛋白激酶表达及纤维化的影响. 乔海兵，顶大有，聂李亚，马素永，许松山，车永哲.解剖学杂志，2011,34（5）：609-611 通讯作者
22. 胸腺素β4调节血管内皮生长因子、层粘连蛋白5表达，促进糖尿病大鼠皮肤损伤愈合.于虎, 马瑞珏, 张朔杨, 李艳, 车永哲*,许松山. 中国糖尿病杂志（核心）,2011,19（1）：60-63通讯作者
23. Construction of ureteral grafts by seeding urothelial cells and bone marrow mesenchymal stem cells into polycaprolactone-lecithin electrospun fibers.Shen J, Fu X, Ou L, Zhang M, Guan Y, Wang K, Che Y, Kong D, Steinhof G, Li W, Yu Y, Ma N.Int J Artif Organs. 2010 Mar;33(3):161-70.
24. 重组胸腺素beta4对大鼠心肌梗死心微血管及血管内皮生长因子表达的影响 乔海兵，聂李亚，马素永，许松山，车永哲* 解剖学杂志（核心） 2010,33（5）：591-594 通讯作者
25. 重组胸腺素β4调节兔角膜烧伤后MMP-2和TIMP-2的表达. 龙安华，李明，王晓坤，司文，李玄德，聂李亚，马素永，车永哲*，许松山 眼科新进展（核心）, 2010, 30(8): 723-726 通讯作者
26. 重组胸腺素β4调节NF-КB表达促进兔角膜碱烧伤后修复 龙安华，李明，王晓坤，司文，李玄德，聂李亚，马素永，车永哲*，许松山 国际眼科杂志（核心）2010,10(5):844-846 通讯作者

六、讲授课程
1．人体解剖学2-1
2. 人体解剖学2-2
3. 人体解剖学（留学生）
4. 人体解剖学（药学、口腔专业）

七、荣誉和奖励

1. 南开大学教学名师（2015）

八、联系方式
1．通讯地址：天津市南开区卫津路94号
2．电话：18602606001
3． E-mail：cheli@nankai.edu.cn