教育经历：

2004.9-2009.7 吉林大学，化学学院，博士学位
 2000.9-2004.7 吉林大学，化学学院，学士学位

工作经历：
 2020.12-至今 南开大学医学院，副研究员

2009.7-2020.12 南开大学医学院，讲师

研究方向：                                                        

小分子化合物的设计、合成及活性研究

主持课题项目：
 1. 高选择性CDK9抗肿瘤抑制剂的设计，合成及生物活性研究，国家自然科学基金青年项目;

2. 靶向CDK4和HDAC多靶点小分子抑制剂的设计、合成及生物活性研究，天津市自然科学基金青年项目;

3. 靶向Legumain蛋白酶抑制剂对乳腺癌细胞生长和转移的治疗作用研究，教育部新教师类基金;

4. 靶向IDO1新型免疫抑制剂的设计、合成及筛选，药物化学生物学国家重点实验室开放课题;
 5. 新型血管内皮生长因子受体（VEGFR-2）抑制剂临床前研究，交叉融合科学基金项目;

6. 靶向Legumain蛋白酶抑制剂对乳腺癌治疗作用的研究，中央高校基本科研业务费专项资金

四、学术兼职
中国抗癌协会会员；中国药理协会会员；中国免疫协会会员

近5年发表论文

1. Y. Li, R. Du, Y. Nie, T. Wang, Y. Ma, Y. Fan*, Design, synthesis and biological assessment of novel CDK4 inhibitor with potent anticancer activity, Bioorganic Chemistry, 2021, 109, 104717.

2. T. Wang, Y. Liu, H. Zhang, Z. Fang, R. Zhang, W. Zhang, Y. Fan*, R. Xiang* Crystal structures of two inhibitors in complex with histone lysinedemethylase 4D (KDM4D) provide new insights for rational drugdesign, Biochemical and Biophysical Research Communications 2021, 554, 71-75.

3. Z. Fang, Y. Liu, R. Zhang, Q. Chen, T. Wang, Wei. Yang, Y. Fan, C. Yu, R. Xiang, S. Yang, Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D, European Journal of Medicinal Chemistry 2021, 223, 113662.

4. C. Wang, X. Wang, Y. Li, T. Wang, Z. Huang, Z. Qin, S. Yang, R. Xiang*, Y. Fan*，Design and optimization of orally spleen tyrosine kinase (SYK) inhibitors for treatment of solid tumor, Bioorganic Chemistry, 2020, 95, 103547.

5. X. Wang, K. Deng, C. Wang, Y. Li, T. Wang, Z. Huang,Y. Ma, P. Sun, Y. Shi, S. Yang, Y. Fan*, R. Xiang* Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control, Journal of enzyme inhibition and medicinal chemistry, 2020, 35, 414-423.

6. Y. Fan ^#, Z. Huang^#, X. Wang, Y. Ma, Y. Li, S. Yang, Y. Shi* Discovery of 12O, a novel oral multi-kinase inhibitor for the treatment of solid tumor, Molecules, 2020, 25, 5199.

7. X. Wang, C. Yu, C. Wang, Y. Ma, T. Wang, Y. Li, Z. Huang, M. Zhou, P. Sun, J. Zheng, S. Yang, Y. Fan*, R. Xiang* Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer, European Journal of Medicinal Chemistry, 2019, 181, 111535 .

8. Z. Huang, B. Zhao, Z. Qin, Y. Li, T. Wang, W. Zhou, J. Zheng, S. Yang, Y. Shi *, Y. Fan*, R. Xiang*, Novel dual inhibitors targeting CDK4 and VEGFR2 synergistically suppressed cancer progression and angiogenesis, European Journal of Medicinal Chemistry, 2019, 181, 111541.

9. B. Zhao, Z. Huang, Z. Qin, Y. Li, T. Wang, L. Wang, W. Zhou, C. Yu, X. Wang, S.Yang, Y. Fan*, Rong Xiang*, Enhancement of Histone Deacetylase Inhibitor Sensitivity in Combination with Cyclin-Dependent Kinase Inhibition for the Treatment of Oral Squamous Cell Carcinoma, Cellular Physiology and Biochemistry, 2019, 53:141-156.

10. Q. Guo, Y. Li, C. Zhang, Z. Huang, X. Wang, Y. Nie, Y. Li, Y. Liu, S. Yang, R. Xiang*, Y. Fan*, Selective and novel cyclin-dependent kinases 4 inhibitor: synthesis and biological evaluation, Med Chem Res, 2018, 27,1666-1678.

11. Q.X. Guo, C.H. Yu, C. Zhang, Y.T. Li, T.Q. Wang, Z. Huang, X. Wang, W. Zhou, Y. Li, Z.X. Qin, C. Wang, R.F. Gao, Y.W. Nie, Y.K. Ma, Y. Shi, J.Y. Zheng, S.Y. Yang, Y. Fan*, R. Xiang*, Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer, J. Med. Chem.,2018, 61. 881-904.

12. Y. Li, X. Luo, Q. Guo, Y. Nie, T. Wang, C. Zhang, Z. Huang, X. Wang, Y. Liu, Y. Chen, J. Zheng, S. Yang, Y. Fan*, R. Xiang*, Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer, J. Med. Chem., 2018, 61, 3166-3192 . 

13. Z. Huang, W. Zhou, Y. Li, M. Cao, T. Wang, Y. Ma, Q. Guo, X. Wang, C. Zhang, C. Zhang, W. Shen, Y. Liu, Y. Chen, J. Zheng, S. Yang, Y. Fan*, R. Xiang*, Novel hybrid molecule overcomes the limited response of solid tumours to HDAC inhibitors via suppressing JAK1-STAT3-BCL2 signalling, Theranostics, 2018, 8, 4995-5011.

14. G. Xu, T. Wang, Y. Li, Z. Huang, X. Wang, J. Zheng, S. Yang, Y. Fan*, R. Xiang*, A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma, Journal of enzyme inhibition and medicinal chemistry, 2018, 33, 1089-1094.

15. W. Shen, X. Zhang, R. Du, Y. Fan, D. Luo, Y. Bao, W. Yang, N. Luo, Y. Luo, S. Zhao. ICAM3 mediates tumor metastasis via a LFA-1-ICAM3-ERM dependent manner., Biochim Biophys Acta Mol Basis Dis., 2018, 8, 2566.

16. Y. Li, Q. Guo, C. Zhang, Z. Huang, T. Wang, X. Wang, X. Wang, G. Xu, Y. Liu, S. Yang,Y. Fan*, R. Xiang*, Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate, Bioorganic & medicinal chemistry letters, 2017, 27, 3231-3237.

讲授课程
医用高分子材料；干细胞与再生医学；医学前沿进展；肿瘤学前沿讲座；文献管理与科研选题；

联系方式
通讯地址：天津市南开区卫津路94号
 E-mail： yanfan@nankai.edu.cn