毛大庆

教授

一、教育经历：

2006/09-2011/06 清华大学 生物学博士；

2001/09-2003/09 比利时鲁汶大学 生物信息学硕士；

1996/09-1999/07 哈尔滨工业大学 环境工程硕士；

1988/09-1992/07 辽宁大学 微生物学学士

二、工作经历：

2017/08-至今      南开大学医学院 教授（2019）；

2012/05-2017/08   天津大学 副教授；

2003/10-2012/05   沈阳药科大学 讲师-副教授（2005）；

三、研究方向和承担项目

研究方向：病原菌耐药机制、病原微生物风险防控

主持的科研项目：

1.       中华人民共和国科学技术部, 国家重点研发计划项目/课题, 2020YFC180690, “场地抗生素及抗性基因健康暴露风险研究”, 2020.11 – 2024.10，452万元, 主持；

2.       国家自然科学基金面上项目，“人体肠道菌群中耐药基因分布和增殖机制研究”, 72万，2019.01 – 2022.12，主持；

3.       国家自然科学基金面上项目，“离子液体促进耐药基因增殖扩散机制研究”，2017.01 – 2020.12，75万元，主持；

4.       国家自然科学基金面上项目，“NDM-1耐药基因在微生物菌群的多态性分布及传播扩散机制”，2015.1-2018.12，88万元，主持；

5.       国家自然科学基金面上项目，“土壤抗生素抗性基因的污染特征和传播扩散机制研究”， 2013.1-2016.12，85万元，主持；

6.       国家自然科学基金面上项目，“污水处理系统中以质粒和整合子携带耐药基因的分子传播机制”，2012.1-2015.12，63万元，主持；

7.       国家自然科学基金面上项目，“环境中持久存在抗生素抗性基因传播机制及生态风险”，2009.1-2011.12，35万元，主持。

四、代表性论文

1.       Zhang, P., D. Mao*, H. Gao, L. Zheng, Z. Chen, Y. Gao, Y. Duan, J. Guo, Y. Luo and H. Ren (2022). Colonization of gut microbiota by plasmid-carrying bacteria is facilitated by evolutionary adaptation to antibiotic treatment. The ISME Journal.

2.       Zhang, P., L. Zheng, Y. Duan, Y. Gao, H. Gao, D. Mao* and Y. Luo (2022). Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis. JOURNAL OF HAZARDOUS MATERIALS 421.

3.       Hou, J., D. Mao#, Y. Zhang, R. Huang, L. Li, X. Wang and Y. Luo (2022). Long-term spatiotemporal variation of antimicrobial resistance genes within the Serratia marcescens population and transmission of S. marcescens revealed by public whole-genome datasets. JOURNAL OF HAZARDOUS MATERIALS 423.

4.       Duan, Y., Z. Chen, L. Tan, X. Wang, Y. Xue, S. Wang, Q. Wang, R. Das, H. Lin, J. Hou, L. Li, D. Mao* and Y. Luo (2019). Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals. Science of The Total Environment: 135674.

5.       Duan, Y., S. Liu, Y. Gao, P. Zhang, D. Mao* and Y. Luo (2021). Macrolides mediate transcriptional activation of the msr(E)-mph(E) operon through histone-like nucleoid-structuring protein (HNS) and cAMP receptor protein (CRP). The Journal of antimicrobial chemotherapy.

6.       Wang, Q., Y. J. Duan, S. P. Wang, L. T. Wang, Z. L. Hou, Y. X. Cui, J. Hou, R. Das, D. Q. Mao and Y. Luo (2020). Occurrence and distribution of clinical and veterinary antibiotics in the faeces of a Chinese population. J Hazard Mater 383: 121129.

7.       Liu, L., Q. Wang, X. Wu, H. Qi, R. Das, H. Lin, J. Shi, S. Wang, J. Yang, Y. Xue, D. Mao and Y. Luo (2020). Vancomycin exposure caused opportunistic pathogens bloom in intestinal microbiome by simulator of the human intestinal microbial ecosystem (SHIME). Environmental Pollution: 114399.

8.       Liu, L., Q. Wang, H. Lin, R. Das, S. Wang, H. Qi, J. Yang, Y. Xue, D. Mao* and Y. Luo (2020). Amoxicillin Increased Functional Pathway Genes and Beta-Lactam Resistance Genes by Pathogens Bloomed in Intestinal Microbiota Using a Simulator of the Human Intestinal Microbial Ecosystem. Frontiers in Microbiology11(1213).

9.       Lin, H., Q. Wang, M. Yuan, L. Liu, Z. Chen, Y. Zhao, R. Das, Y. Duan, X. Xu, Y. Xue, Y. Luo and D. Mao* (2020). The prolonged disruption of a single-course amoxicillin on mice gut microbiota and resistome, and recovery by inulin, Bifidobacterium longum and fecal microbiota transplantation. Environmental Pollution: 114651.

10.    Lin, H., Q. Wang, L. Liu, Z. Chen, R. Das, Y. Zhao, D. Mao* and Y. Luo (2020). Colonization of Mice With Amoxicillin-Associated Klebsiella variicola Drives Inflammation via Th1 Induction and Treg Inhibition. Frontiers in Microbiology11(1256).

11.    Duan, Y., H. Gao, L. Zheng, S. Liu, Y. Cao, S. Zhu, Z. Wu, H. Ren, D. Mao* and Y. Luo (2020). Antibiotic Resistance and Virulence of Extraintestinal Pathogenic Escherichia coli (ExPEC) Vary According to Molecular Types. FRONTIERS IN MICROBIOLOGY11.

12.    Xu, Y., X. Wang, T. Lu, D. Mao* and Y. Luo (2019). Metal impacts on the persistence and proliferation of β-lactam resistance genes in Xiangjiang River, China. Environmental Science and Pollution Research.

13.    Tan, L., F. Wang, M. Liang, X. Wang, R. Das, D. Mao* and Y. Luo (2019). Antibiotic resistance genes attenuated with salt accumulation in saline soil. Journal of Hazardous Materials374: 35-42.

14.    Hou, J., Z. Chen, J. Gao, Y. Xie, L. Li, S. Qin, Q. Wang, D. Mao* and Y. Luo (2019). Simultaneous removal of antibiotics and antibiotic resistance genes from pharmaceutical wastewater using the combinations of up-flow anaerobic sludge bed, anoxic-oxic tank, and advanced oxidation technologies. Water Research159: 511-520.

15.    Zhou, H., X. L. Wang, Z. H. Li, Y. Kuang, D. Q. Mao* and Y. Luo (2018). Occurrence and Distribution of Urban Dust-Associated Bacterial Antibiotic Resistance in Northern China. Environmental Science & Technology Letters5(2): 50-55.

16.    Tan, L., L. Y. Li, N. Ashbolt, X. L. Wang, Y. X. Cui, X. Zhu, Y. Xu, Y. Yang, D. Q. Mao* and Y. Luo (2018). Arctic antibiotic resistance gene contamination, a result of anthropogenic activities and natural origin. Science of the Total Environment621: 1176-1184.

17.    Dang, B., D. Mao*, Y. Xu and Y. Luo (2017). Conjugative multi-resistant plasmids in Haihe River and their impacts on the abundance and spatial distribution of antibiotic resistance genes. Water Research111: 81-91.

18.    Yang, F., L. Huang, L. Li, Y. Yang, D. Mao* and Y. Luo (2017). Discharge of KPC-2 genes from the WWTPs contributed to their enriched abundance in the receiving river. The Science of the total environment581-582: 136-143.

19.    Xu, Y., J. Xu, D. Mao* and Y. Luo (2017). Effect of the selective pressure of sub-lethal level of heavy metals on the fate and distribution of ARGs in the catchment scale. Environmental Pollution220: 900-908.

20.    Yang, F., D. Mao*, H. Zhou, X. Wang and Y. Luo (2016). Propagation of New Delhi Metallo-beta-lactamase Genes (bla(NDM-1)) from a Wastewater Treatment Plant to Its Receiving River. Environmental Science & Technology Letters3(4): 138-143.

21.    Yang, F., D. Mao*, H. Zhou and Y. Luo (2016). Prevalence and Fate of Carbapenemase Genes in a Wastewater Treatment Plant in Northern China. Plos One11(5).

22.    Hou, J., C. Wang, D. Mao* and Y. Luo (2016). The occurrence and fate of tetracyclines in two pharmaceutical wastewater treatment plants of Northern China. Environmental Science and Pollution Research23(2): 1722-1731.

23.    Dang, B., Y. Xu, D. Mao* and Y. Luo (2016). Complete nucleotide sequence of plasmid pNA6 reveals the high plasticity of IncU family plasmids. Gene591(1): 74-79.

24.    Dang, B., D. Mao* and Y. Luo (2016). Complete Nucleotide Sequence of pGA45, a 140,698-bp IncFII(Y) Plasmid Encoding bla(IMI-3)-Mediated Carbapenem Resistance, from River Sediment. Frontiers in Microbiology7.

25.    Dang, B., D. Mao* and Y. Luo (2016). Complete Nucleotide Sequence of IncP-1 beta Plasmid pDTC28 Reveals a Non-Functional Variant of the bla(GES)-Type Gene. Plos One11(5).

26.    Wang, Q., D. Mao*, Q. Mu and Y. Luo (2015). Enhanced Horizontal Transfer of Antibiotic Resistance Genes in Freshwater Microcosms Induced by an Ionic Liquid. Plos One10(5).

27.    Wang, Q., D. Mao* and Y. Luo (2015). Ionic Liquid Facilitates the Conjugative Transfer of Antibiotic Resistance Genes Mediated by Plasmid RP4. Environmental Science & Technology49(14): 8731-8740.

28.    Wang, Q., Q. Lu, D. Mao*, Y. Cui and Y. Luo (2015). The horizontal transfer of antibiotic resistance genes is enhanced by ionic liquid with different structure of varying alkyl chain length. Frontiers in Microbiology6.

29.    Wang, J., D. Mao*, Q. Mu and Y. Luo (2015). Fate and proliferation of typical antibiotic resistance genes in five full-scale pharmaceutical wastewater treatment plants. Science of the Total Environment526: 366-373.

30.    Mu, Q., J. Li, Y. Sun, D. Mao*, Q. Wang and Y. Luo (2015). Occurrence of sulfonamide-, tetracycline-, plasmid-mediated quinolone- and macrolide-resistance genes in livestock feedlots in Northern China. Environmental Science and Pollution Research22(9): 6932-6940.

31.    Mao, D#., S. Yu, M. Rysz, Y. Luo, F. Yang, F. Li, J. Hou, Q. Mu and P. J. J. Alvarez (2015). Prevalence and proliferation of antibiotic resistance genes in two municipal wastewater treatment plants. Water Research85: 458-466

32.    Hou, J., W. Wan, D. Mao*, C. Wang, Q. Mu, S. Qin and Y. Luo (2015). Occurrence and distribution of sulfonamides, tetracyclines, quinolones, macrolides, and nitrofurans in livestock manure and amended soils of Northern China. Environmental Science and Pollution Research22(6): 4545-4554.

33.    Mao, D.#, Y. Luo, J. Mathieu, Q. Wang, L. Feng, Q. Mu, C. Feng and P. J. J. Alvarez (2014). Persistence of Extracellular DNA in River Sediment Facilitates Antibiotic Resistance Gene Propagation. Environmental Science & Technology48(1): 71-78.

34.    Luo, Y., F. Yang, J. Mathieu, D. Mao*, Q. Wang and P. J. J. Alvarez (2014). Proliferation of Multidrug-Resistant New Delhi Metallo-beta-lactamase Genes in Municipal Wastewater Treatment Plants in Northern China. Environmental Science & Technology Letters1(1): 26-30.

35.    Luo, Y., Q. Wang, Q. Lu, Q. Mu and D. Mao* (2014). An Ionic Liquid Facilitates the Proliferation of Antibiotic Resistance Genes Mediated by Class I Integrons. Environmental Science & Technology Letters1(5): 266-270.

36.    Gao, P., D. Mao, Y. Luo, L. Wang, B. Xu and L. Xu (2012). Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment. Water Research46(7): 2355-2364.

五、联系方式

1．通讯地址：天津南开区卫津路94号

2. E-mail：maodq@nankai.edu.cn