姓名：张博崴

职称：副教授

一、教育经历

2014.9-2018.7 大连理工大学，生物化工专业，博士学位

2011.9-2014.7 大连理工大学，生物化工专业，硕士学位

2007.9-2011.6 辽宁大学，生物技术专业，学士学位

二、工作经历

2023.12-至今南开大学医学院，副教授

2018.07-2023.12，南开大学医学院，讲师

三、研究方向

1. 膳食活性成分与慢病干预

2. 膳食营养与肠道菌群的相互作用

3. 营养素代谢的个体差异与精准营养

承担科研项目

1. 国家自然基金青年项目（32101962，30万，主持）

白藜芦醇的个体差异化菌群代谢物调控小鼠糖代谢的作用机制

2. 国家重点研发计划子课题（2019YFC1605005，75万，主持）

多种食物致敏原精准快速检测技术标准及配套产品研发

3. 中国食品科学技术学会食品科技基金（2022-F07，20万，主持）

母乳寡糖结合态唾液酸与益生菌协同干预衰老的作用机制研究

四、近5年发表论文

从事膳食功能成分与肠道微生物互作及精准营养研究，主要关注于营养素、植物化合物等成分的肠道代谢及慢病干预作用。近五年在该领域发表论文50余篇，其中以第一作者发表SCI论文23篇（中科院一区15篇），授权国家发明专利8项。

1. Liu X^#; Zhang B^#; Zhang Y; Li W; Yin J; Shi A; Wang J; Wang S*; 2′-Fucosyllactose Promotes Colonization of Akkermansia muciniphila and Prevents Colitis In Vitro and in Mice, Journal of Agricultural and Food Chemistry, 2024, 72(9): 4765-4776.

2. Wu J^#; Zhang B^#; Liu X^#; Peng L; Liu J; Hu Y; Ji X; Lv H; Wang S*; Current gut-on-a-chip platforms for clarifying the interactions between diet, gut microbiota, and host health, Trends in Food Science & Technology, 2023, 134: 1-12.

3. Zhang B; Zhang Y; Liu X; Zhao C; Yin J; Li X; Zhang X; Wang J; Wang S*; Distinctive anti-inflammatory effects of resveratrol, dihydroresveratrol, and 3-(4-hydroxyphenyl)-propionic acid on DSS-induced colitis in pseudo-germ-free mice, Food Chemistry, 2023, 400: 133904.

4. Zhou X^#; Zhang B^#; Zhao X; Zhang P; Guo J; Zhuang Y; Wang S*; Coffee Leaf Tea Extracts Improve Hyperuricemia Nephropathy and Its Associated Negative Effect in Gut Microbiota and Amino Acid Metabolism in Rats, Journal of Agricultural and Food Chemistry, 2023, 71(46): 17775-17787.

5. Yin J, Zhang Y, Liu X, Li W, Hu Y, Zhang B*, Wang S*. Gut Microbiota-Derived Indole Derivatives Alleviate Neurodegeneration in Aging through Activating GPR30/AMPK/SIRT1 Pathway. Molecular Nutrition & Food Research. 2023, 67(9):e2200739.

6. Zhang B; Zhang Y; Xing X; Wang S*; Health benefits of dietary polyphenols: Insight into interindividual variability in absorption and metabolism, Current Opinion in Food Science, 2022, 48: 100941.

7. Zhang B; Zhang Y; Liu X; Yin J; Li X; Zhang X; Xing X; Wang J; Wang S*; Differential protective effect of resveratrol and its microbial metabolites on intestinal barrier dysfunction is mediated by the AMPK pathway, Journal of Agricultural and Food Chemistry, 2022, 70(36): 11301-11313.

8. Zhang B; Zhao C; Zhang X; Li X; Zhang Y; Liu X; Yin J; Li X; Wang J; Wang S#; An Elemental Diet Enriched in Amino Acids Alters the Gut Microbial Community and Prevents Colonic Mucus Degradation in Mice with Colitis, mSystems, 2022, 7(6): e00883-22.

9. Zhang B; Rao X; Zhang Y; Dai W; Xu Y; Zhao C; Chen Z; Wang J; Fan D; Wang X; Wang S*; Protective Effect of Foxtail Millet Protein Hydrolysate on Ethanol and Pyloric Ligation-Induced Gastric Ulcers in Mice, Antioxidants, 2022, 11(12): 2459.

10. Zhang B; Xu Y; Zhao C; Zhang Y; Lv H; Ji X; Wang J; Pang W; Wang X; Wang S*; Protective effects of bioactive peptides in foxtail millet protein hydrolysates against experimental colitis in mice, Food & Function, 2022, 13(5): 2594-2605.

11. Zhang B; Xu Y; Lv H; Pang W; Wang J; Ma H; Wang S*; Intestinal pharmacokinetics of resveratrol and regulatory effects of resveratrol metabolites on gut barrier and gut microbiota, Food Chemistry, 2021, 357: 129532.

专利：

1. 董悦生，张博崴，孙文龙，桑元斌，于晓霞，修志龙. 一种具有α-糖苷酶抑制活性的药物组合物及其应用，专利号：ZL201510081001.8

2. 董悦生，张博崴，文琛，孙文龙，余娜，修志龙. 具有α-淀粉酶协同抑制活性的组合物，申请号：201710466865.0

五、荣誉和奖励

无

六、联系方式

1. 通讯地址：天津市津南区南开大津南校区，医学院334

2. E-mail：bwzhang@nankai.edu.cn