胡耀中

姓名:胡耀中

职称:副教授

一、教育经历

2014.09-2018.01比利时布鲁塞尔自由大学,生物工程科学专业,博士学位

2013.09-2017.12天津大学,制药工程专业,博士学位

2010.09-2013.07天津大学,生物化工专业,硕士学位

2005.09-2009.07天津大学,生物工程专业,本科学位

二、工作经历

2022.12-至今,南开大学医学院,副教授

2018.07-2022.12,南开大学医学院,讲师

三、研究方向(包括承担课题项目)

1.抗体药物的研究与开发

2.食品安全检测研究

3.膳食营养与免疫学研究

主持科研项目

1. 国家重点研发计划青年科学家项目课题(2022YFF110240060万)

合成生物食品微生物防控关键技术开发

2. 国家自然基金面上项目(3227240355万)

基于纳米抗体的食物过敏原高通量检测及降敏机制研究

3. 国家自然基金青年项目(3190177930万)

基于纳米抗体的Macadamia过敏原致敏机制研究与痕量检测

四、近5年发表论文

申请人长期从事食品营养与安全研究,一方面聚焦食品风险因子特异性抗体互作机制与免疫检测机理,另一方面指导和开展膳食营养与免疫研究,关注膳食营养物质免疫调控功能及其对机体健康和稳态干预,申请人在食品营养与安全领域已发表研究论文40余篇,申请国家发明专利13件,已授权8件。

1.   Hu, Yaozhong; Gu, Jiaxin; Wang, Yi; Lin, Jing; Yu, Huaning; Yang, Feier; Wu, Sihao; Yin, Jia; Lv, Huan; Ji, Xuemeng; Wang, Shuo; Promotion Effect of EGCG on the Raised Expression of IL-23 through the Signaling of STAT3-BATF2-c-JUN/ATF2, Journal of Agricultural and Food Chemistry, 2021, 69(28): 7898-7909.

2.   Hu, Yaozhong; Gu, Jiaxin; Lin, Jing; Wang, Yi; Yang, Feier; Yin, Jia; Yu, Zhenting; Wu, Sihao; Lv, Huan; Ji, Xuemeng; Wang, Shuo; (-)-Epigallocatechin-3-gallate (EGCG) modulates polarized macrophages to suppress M1 phenotype and promote M2 polarization in vitro and in vivo, Journal of Functional Foods, 2021, 87: 104743.

3.   Hu Y., Wu S., Wang Y., Lin J., Sun Y., Zhang C., Gu J., Yang F., Lv H., Ji X., Zhang Y., Muyldermans S., Wang S., Unbiased Immunization Strategy Yielding Specific Nanobodies against Macadamia Allergen of Vicilin-like Protein for Immunoassay Development, Journal of Agricultural and Food Chemistry, 2021, 69(17):5178-5188.

4.   Hu Y., Zhang C., Yang F., Lin J., Wang Y., Wu S., Sun Y., Zhang B., Lv H., Ji X., Lu Y., Muyldermans S., Wang S., Selection of Specific Nanobodies against Lupine Allergen Lup an 1 for Immunoassay Development, Foods, 2021, 10(10):2428.

5.   Yaozhong Hu; Yi Wang; Jing Lin; Sihao Wu; Serge Muyldermans; Shuo Wang; Versatile Application of Nanobodies for Food Allergen Detection and Allergy Immunotherapy, Journal of Agricultural and Food Chemistry, 2022, 70(29): 8901-8912.

6.   Yaozhong Hu; Yi Wang; Linqing Nie; Jing Lin; Sihao Wu; Shijie Li; Jing Wu; Xuemeng Ji; Huan Lv; Serge Muyldermans; Shuo Wang; Exploration of Specific Nanobodies As Immunological Reagents to Detect Milk Allergen of β-Lactoglobulin without Interference of Hydrolytic Peptides, Journal of Agricultural and Food Chemistry, 2022, 7(48): 15271-15282.

7.   Hu Y., Zhang C., Lin J., Wang Y., Wu S., Sun Y., Zhang B., Lv H., Ji X., Lu Y., Shuo Wang, Selection of specific nanobodies against peanut allergen through unbiased immunization strategy and the developed immuno-assay, Food Science and Human Wellness, 2023, 12:745-754.

8.   Hu Y., Lin J., Peng L., Wang Y., Wu S., Ji X., Lv H., Wu J., Zhang Y., Wang S., Nanobody-Based Electrochemical Immunoassay for Sensitive Detection of Peanut Allergen Ara h 1, Journal of Agricultural and Food Chemistry, 2023, 71(19):7535-7545.

9.   Hu Y, Wang Y, Lin J, Wu S, Lv H, Ji X, Wang S. Identification and Characterization of Specific Nanobodies against Trop-2 for Tumor Targeting. Int J Mol Sci. 2022 Jul 19;23(14):7942.

五、荣誉和奖励

六、联系方式

1.通讯地址:天津市津南区同砚路38

2.E-mailyzhu@nankai.edu.cn

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