姓名：吴佳仪

职称：讲师

一、教育经历

20013/09-2019/01，中国科学院大学，中国科学院生物物理研究所，生物化学与分子生物学专业，博士

2009/09-2013/06，南开大学，生命科学学院，生物技术专业，学士

二、工作经历

2019/10至今，南开大学，医学院，讲师

三、研究方向（包括承担课题项目）

1. 非编码RNA调控肿瘤干细胞自我更新的机制研究

2. 肠道干细胞自我更新的机制研究

四、近5年发表论文

1.   Wu J#, Zhu P#, Lu T#, Du Y#, Wang Y, He L, Ye B, Liu B, Wang J, Yang L, Wang J, Gu Y, Lan J, Hao Y, He L, Fan Z. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling. J Hepatol. 70(5), 918-929, 2019.

2.   Zhu P#, Wu J#, Wang Y#, Zhu X#, Lu T#, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z. LncGata6 maintains stemness of intestinal stem cells and drives intestinal tumorigenesis. Nat Cell Biol. 20(10),1134-1144, 2018.

3.   Zhu P#, Zhu X#, Wu J#, He L#, Lu T#, Liu B, Wang Y, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 20(2), 183-194, 2019.

4.   Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y, Fan Z. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO J. Online ahead of print.

5.   Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y, Fan Z. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. J Exp Med. 216(11), 2653-2668, 2019.

6.   Wang Y, Zhu P, Zhu X, Wang J, Luo J, Meng S, Wu J, He L, Du Y, He L, Chen R, Tian Y, Fan Z. Long noncoding RNA LncHand2 promotes liver regeneration via initiating Nkx1-2-induced c-Met signaling. J Hepatol. 69(4), 861-872, 2018.

7.   Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R, Tian Y, Fan Z. LncKdm2b controls pluripotency of embryonic stem cells and early embryogenesis via activation of transcription factor Zbtb3.EMBO J. 37(8), e97174, 2018.

8.   Ye B, Liu B, Yang L, Huang G, Hao L, Xia P, Wang S, Du Y, Qin X, Zhu P, Wu J, Sakaguchi N, Zhang J, Fan Z. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 8(1), 1518, 2017.

9.   Yan X, Zhang D, Wu W, Wu S, Qian J, Hao Y, Yan F, Zhu P, Wu J, Huang G, Huang Y, Luo J, Liu X, Liu B, Chen X, Du Y, Chen RS, Fan Z. Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a. Cancer Res. 77(23), 6704-6716, 2017.

10.Liu B, Ye B, Zhu X, Huang G, Yang L, Zhu P, Du Y, Wu J, Meng S, Tian Y, Fan Z. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nat Commun. 8(1), 231, 2017.

11.Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R, Tian Y, Fan Z. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 18(5), 499-508, 2017.

12.Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 7, 13608, 2016.

13.Zhu P, Wang Y, Huang G, Ye B, Liu B, Wu J, Du Y, He L, Fan Z. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 23(7), 631-639, 2016.

14.Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. J Clin Invest. 125(10), 3795-3808, 2015.

五、联系方式

1．通讯地址：天津市南开区卫津路94号

2．电话：022-23509482

3．E-mail：wujiayi@nankai.edu.cn