Education 

Academic Career

Research Areas

The GUO group takes advantage of molecular recognition and self-assembly of calixarenes to engineer new smart biomaterials to achieve precision medicine. Ongoing projects within the laboratory include:

(1)   Inhibition of amyloid fibrillation

(2)   Supramolecular phototheranostics

(3)   Fluorescence sensing for bio-molecules

(4)   Bio-membrane transport activated by calixarenes

Honors& Awards

2019, National Leader in Science and Technology Innovation

2018, Youth Science and Technology Innovation Leader (Ministry of Science and Technology of China)

2018, Tianjin Youth Science and Technology Innovation Leader

2015, Tianjin Natural Science Award (the First-Rank)

2014, Tianjin Excellent Young Science & Technology Talent

2014, Tianjin Program for Support of Top-notch Young Professionals

2013, The 100 Young-Academic-Leader Project of Nankai University

2013, The Science Funds for Excellent Youth (National Natural Science Foundation of China)

Professional Memberships

2021-2025, Member, Editorial Board of Chinese Chemical Letters.

2021-, Member, Editorial Board of Supramolecular Materials.

2017- Member, Editorial Board of Frontiers in Chemistry.

Selected Publications

1. Wen-Chao Geng^#, Zhongju Ye^#, Zhe Zheng, Jie Gao, Juan-Juan Li, Muhammad Raza Shah, Lehui Xiao* and Dong-Sheng Guo* Supramolecular Bioimaging through Signal Amplification by Combining Indicator Displacement Assay with Förster Resonance Energy Transfer Angew. Chem. Int. Ed., 2021, 60, 19614-19619.

2. Yu-Chen Pan, Andrea Barba-Bon, Han-Wen Tian, Fei Ding, Andrea Hennig, Werner M. Nau and Dong-Sheng Guo* An Amphiphilic Sulfonatocalix[5]arene as an Activator for Membrane Transport of Lysine-rich Peptides and Proteins Angew. Chem. Int. Ed., 2021, 60, 1875-1882.

3. Yu-Chen Pan, Xin-Yue Hu and Dong-Sheng Guo* Biomedical Applications of Calixarenes: State-of-the-Art and Perspectives Angew. Chem. Int. Ed., 2021, 60, 2768-2794.

4. Yu-Chen Pan, Yu-Xin Yue, Xin-Yue Hu, Hua-Bin Li and Dong-Sheng Guo* A Supramolecular Antidote to Macromolecular Toxins Prepared through Coassembly of Macrocyclic Amphiphiles Adv. Mater., 2021, 33, 2104310.

5. Zhanzhan Zhang^#, Yu-Xin Yue^#, Lina Xu, Ying Wang, Wen-Chao Geng, Juan-Juan Li, Xianglei Kong, Zhixin Zhao, Yadan Zheng, Yu Zhao, Linqi Shi*, Dong-Sheng Guo* and Yang Liu* Macrocyclic-Amphiphile-Based Self-Assembled Nanoparticles for Ratiometric Delivery of Therapeutic Combinations to Tumors Adv. Mater., 2021, 33, 2007719.

6. Hui Wang^#, Xinxin Xu^#, Yu-Chen Pan^#, Yuxing Yan, Xin-Yue Hu, Runwen Chen, Bart Jan Ravoo, Dong-Sheng Guo* and Tao Zhang* Recognition and Removal of Amyloid-b by a Heteromultivalent Macrocyclic Coassembly: A Potential Strategy for the Treatment of Alzheimer’s Disease Adv. Mater., 2021, 33, 2006483.

7. Tian-Xing Zhang^#, Zhan-Zhan Zhang^#, Yu-Xin Yue^#, Xin-Yue Hue, Fan Huang*, Linqi Shi*, Yang Liu* and Dong-Sheng Guo* A General Hypoxia-Responsive Molecular Container for Tumor-Targeted Therapy Adv. Mater., 2020, 32, 1908435.

8. Wen-Chao Geng^#, Dongmei Zhang^#, Chu Gong, Zhihao Li, Kevin Barraza, Jesse L. Beauchamp*, Dong-Sheng Guo* and Xinxing Zhang* Host-Guest Complexation of Amphiphilic Molecules at the Air-Water Interface Prevents Oxidation by Hydroxyl Radicals and Singlet Oxygen Angew. Chem. Int. Ed., 2020, 59, 12684-12688.

9. Wen-Chao Geng, Jonathan L. Sessler* and Dong-Sheng Guo* Supramolecular Prodrugs Based on Host-Guest Interactions Chem. Soc. Rev., 2020, 49, 2303-2315.

10. Yu-Chen Pan^#, Hui Wang^#, Xinxin Xu^#, Han-Wen Tian, Hong Zhao, Xin-Yue Hu, Yu Zhao, Yang Liu, Guihua Ding, Qingbin Meng, Bart Jan Ravoo, Tao Zhang* and Dong-Sheng Guo* Coassembly of Macrocyclic Amphiphiles for Anti-b-Amyloid Therapy of Alzheimer’s Disease CCS Chem., 2020, 2, 2485-2497.

11. Zhe Xu, Shao-Rui Jia, Wei Wang, Zhi Yuan, Bart Jan Ravoo* and Dong-Sheng Guo* Peptide Recognition by Co-Assembly of Cyclodextrin and Calixarene Amphiphiles Enables Inhibition of Amyloid Fibrillation Nat. Chem., 2019, 11, 86–93.

12. Wen-Chao Geng, Shaorui Jia, Zhe Zheng, Zhihao Li, Dan Ding and Dong-Sheng Guo* A Noncovalent Fluorescence Turn-on Strategy for Hypoxia Imaging Angew. Chem. Int. Ed., 2019, 58, 2377–2381.

13. Zhe Zheng, Huijuan Yu, Wen-Chao Geng, Xin-Yue Hu, Yu-Ying Wang, Zhihao Li, Yuefei Wang and Dong-Sheng Guo* Guanidinocalix[5]arene for Sensitive Fluorescence Detection and Magnetic Removal of Perfluorinated Pollutants Nat. Commun., 2019, 10, 5762.

14. Jie Gao, Jun Li, Wen-Chao Geng, Fang-Yuan Chen, Xingchen Duan, Zhe Zheng, Dan Ding* and Dong-Sheng Guo* Biomarker Displacement Activation: A General Host-Guest Strategy for Targeted Phototheranostics in Vivo J. Am. Chem. Soc., 2018, 140, 4945–4953.

15. Zhe Zheng, Wen-Chao Geng, Jie Gao, Yu-Ying Wang, Hongwei Sun and Dong-Sheng Guo* Ultrasensitive and Specific Fluorescence Detection of a Cancer Biomarker via Nanomolar Binding to a Guanidinium-modified Calixarene Chem. Sci., 2018, 9, 2087–2091.

Patents

1. 郭东升，化合物及包含所述化合物的试剂盒，

   专利号：ZL 2017 1 1391952.0，授权公告日：2019/12/24

2. 郭东升，化合物、纳米超分子药物载体及包含所述纳米超分子药物载体的药物，

   专利号：ZL 2018 1 0057869.8，授权公告日：2019/12/24

3. 郭东升，徐喆，彭姝，两亲环糊精CD与两亲杯芳烃CA的纳米超分子共组装体及制备方法和应用，

   专利号：ZL 2018 1 0328452.0，授权公告日：2021/02/05

Commercialization of Scientific and Research Findings

1. 国家自然科学基金区域创新发展联合基金重点项目，U20A20259，乏氧响应的主客体药物递送体系，

   2021/01-2024/12，310.6万元，在研，主持

2. 南开大学—沧州渤海新区绿色化工研究院孵化基金项目，NCC2020FH04，新型超分子药用辅料的研发，

   2020/01-今，250万元，在研，主持

3. 国家自然科学基金国际（地区）合作与交流项目，31961143004，减负增效超分子抗肿瘤纳米药物，

   2019/07-2022/06，206.2万元，在研，主持

4. 国家“万人计划”科技创新领军人才，两亲杯芳烃自组装生物医用纳米材料，

   2019/02-2022/02，80万元，结题，主持