刘斌

       刘斌，南开大学泰达生物技术研究院副院长，“分子微生物学与技术”教育部重点实验室主任、“微生物功能基因组与检测技术”教育部工程研究中心主任。天津市杰青，南开大学百名青年学术带头人。

   长期进行致病菌进化机制和致病性机理的研究，在该领域具有丰富经验。作为通讯/第一作者，已累计在Nature Microbiology，PNAS，Nature Communications，Science Signaling，FEMS Microbiology Reviews, Nucleic Acids Research，mBio，Gut Microbes，Metabolic Engineering等期刊发表70篇论文。获2018年法国梅里埃研究院青年科学家奖。担任法国国家科研署(French National Research Agency)项目评审专家。

通讯/第一作者发表的部分论文的列表：

 (*corresponding author, #co-first author, IF, impact factor)

1. Yutao Liu, Jialin Wu, Ruiying Liu, Fan Li, Leyan Xuan, Qian Wang, Dan Li, XinTong Chen, Hao Sun, Xiaoya Li, Chen Jin, Di Huang, Linxing Li, Guosheng Tang, Bin Liu(*). 2024. Vibrio cholerae virulence is blocked by chitosan oligosaccharide-mediated inhibition of ChsR activity. Nat Microbiol. doi: 10.1038/s41564-024-01823-6 (IF: 21)

2. Liu B(*), Liu Y, Yang B, Wang Q, Liu X, Qin J, Zhao K, Li F, Feng X, Li L, Wu P, Liu M, Zhu S, Feng L, Wang L(*). 2022. Escherichia coli O157:H7 senses microbiota-produced riboflavin to increase its virulence in the gut. PNAS. 119(48):e2212436119. (IF:12.8)

3. Linxing Li, Bin Yang, Jing Wang, Yi Wei, Binbin Xiang, Yutao Liu, Pan Wu, Wanwu Li, Yanling Wang, Xinyu Zhao, Jingliang Qin, Miaomiao Liu, Ruiying Liu, Guozhen Ma, Tian Fu, Min Wang, Bin Liu(*). 2024. CobB-mediated deacetylation of the chaperone CesA regulates Escherichia coli O157:H7 virulence. Gut Microbes. 16(1):2331435. (IF:12.0)

4. Xingmei Liu, Yutao Liu, Xinyu Zhao, Xueping Li, Ting Yao, Ruiying Liu, Qian Wang, Qiushi Wang, Dan Li, Xintong Chen, Bin Liu(*), Lu Feng(*). 2024. Salmonella enterica serovar Typhimurium remodels mitochondrial dynamics of macrophages via the T3SS effector SipA to promote intracellular proliferation. Gut Microbes. 16(1):2316932. (IF:12.0)

5. Bin Liu#, Lingyan Jiang#, Yutao Liu#, Hongmin Sun, Jun Yan, Chenbo Kang, Bin Yang. 2023. Enterohaemorrhagic E. coli utilizes host- and microbiota-derived L-malate as a signaling molecule for intestinal colonization. Nat Commun.14(1):7227. (IF:14.7)

6. Jia T, Wu P, Liu B, Liu M, Mu H, Liu D, Huang M, Li L, Wei Y, Wang L, Yang Q, Liu Y, Yang B, Huang D, Yang L, Liu B(*). 2023. The phosphate-induced small RNA EsrL promotes E. coli virulence, biofilm formation, and intestinal colonization. Sci Signal 16(767):eabm0488. (IF:9.5)

7.  Wu J, Liu Y, Li W, Li F, Liu R, Sun H, Qin J, Feng X, Huang D, Liu B(*). 2022. MlrA, a MerR family regulator in Vibrio cholerae, senses the anaerobic signal in the small intestine of the host to promote bacterial intestinal colonization. Gut Microbes 14(1):2143216. (IF:12.0)

8. Liu Y(#), Liu B(#), Xu T(#), Wang Q, Li W, Wu J, Zheng X, Liu B, Liu R, Liu X, Guo X, Feng L, Wang L. 2021. A fructose/H+ symporter controlled by a LacI-type regulator promotes survival of pandemic Vibrio cholerae in seawater. Nat Commun 12(1):4649. (IF:14.7)

9. Jia T, Liu B, Mu H, Qian C, Wang L, Li L, Lu G, Zhu W, Guo X, Yang B, Huang D, Feng L, Liu B(*). 2021. A novel small RNA promotes motility and virulence of enterohemorrhagic Escherichia coli O157:H7 in response to ammonium. mBio 12(2): e03605-20. (IF:7.8)

10. Liu B(#), Qian C(#), Wu P, Li X, Liu Y, Mu H, Huang M, Zhang Y, Jia T, Wang Y, Wang L, Zhang X, Huang D, Yang B, Feng L, Wang L. 2021. Attachment of enterohemorrhagic Escherichia coli to host cells reduces O antigen chain length at the infection site that promotes infection. mBio 12(6): e0269221. (IF:7.8)

11. Liu B, Furevi A, Perepelov AV, Guo X, Cao H, Wang Q, Reeves PR, Knirel YA, Wang L, Widmalm G. 2020. Structure and genetics of Escherichia coli O antigens. FEMS Microbiol Rev 44(6):655-683. (IF:15.2)

12. Yuan J, Jiang X, Zhang H, Bai J, Zhang J, Wang Y, Lu G, Xu H, Liu H(*), Liu B(*), Huang D (*). 2021. Construction and optimization of a microbial platform for sustainable biosynthesis of poly-N-acetyllactosamine glycoprotein in the cytoplasm for detecting tumor biomarker galectin-3. Green Chem 23:2668-2684. (IF:11.0)

13. Wang M, Wang L, Wu P, Chen T, Zhu Y, Zhang Y, Wei Y, Qian C, Wang Y, Liu B(*). 2019. Genomics and experimental analysis reveal a novel factor contributing to the virulence of Cronobacter sakazakii strains associated with neonate infection. J Infect Dis 220(2):306-315. (IF:7.8)

14. Liu B(#), Wang J(#), Wang L, Ding P, Yang P, Yang B. 2020. Transcriptional activator OvrA encoded in O island 19 modulates virulence gene expression in enterohemorrhagic Escherichia coli O157:H7. J Infect Dis 221(5):820-829. (IF:7.8)

15. Hu D(#), Liu B(#), Feng L, Ding P, Guo X, Wang M, Cao B, Reeves PR, Wang L. 2016. Origins of the current seventh cholera pandemic, Proc Natl Acad Sci USA 113:E7730-E7739. (IF:12.8)

16.  Huang D, Wang Y, Zhang J, Xu H, Bai J, Zhang H, Jiang X, Yuan J, Lu G, Jiang L, Liao X, Liu B(*), Liu H(*). 2021. Integrative metabolomic and transcriptomic analyses uncover metabolic alterations and pigment diversity in monascus in response to different nitrogen sources. mSystems 6(5): e0080721. (IF:7.3)

17. Wang L, Zhu W, Lu G, Wu P, Wei Y, Su Y, Jia T, Li L, Guo X, Huang M, Yang Q, Huang D(*), Liu B(*). 2021. In silico species identification and serotyping for Cronobacter isolates by use of whole-genome sequencing data. Int J Food Microbiol 358:109405. (IF:5.9)

18. Liu B, Guo X, Wang J, Wu P, Li S, Feng L, Liu B(*), Wang L(*). 2021. Development of a molecular serotyping scheme for Morganella morganii. Front Microbiol 12:791165. (IF:6.1)

19. Liu Y(#), Liu B(#), Yang P, Wang T, Chang Z, Wang J, Wang Q, Li W, Wu J, Huang D, Jiang L, Yang B. 2019. LysR-type transcriptional regulator OvrB encoded in O island 9 drives enterohemorrhagic Escherichia coli O157:H7 virulence. Virulence 10:783-792. (IF:5.4)

20. Jiang L, Wang P, Li X, Lv R, Wang L, Yang B, Huang D, Feng L(*), Liu B(*). 2020. PagR mediates the precise regulation of Salmonella pathogenicity island 2 gene expression in response to magnesium and phosphate signals in Salmonella Typhimurium. Cell Microbiol 22(2):e13125. (IF:4.1)

21. Hu D, Yin Z, Yuan C, Yang P, Qian C, Wei Y, Zhang S, Wang Y, Yuan J, Wang M, Reeves PR, Tu L, Chen M(*), Huang D(*), Liu B(*). 2019. Changing molecular epidemiology of Vibrio cholerae outbreaks in Shanghai, China. mSystems 4(6):e00561-19. (IF:7.3)

22. Zhang X, Yuan J, Sun Y, Li S, Gao Y, Yu Y, Liu C, Wang Q, Lv X, Zhang X, Ma KY, Wang X, Lin W, Wang L, Zhu X, Zhang C, Zhang J, Jin S, Yu K, Kong J, Xu P, Chen J, Zhang H, Sorgeloos P, Sagi A, Alcivar-Warren A, Liu Z, Wang L, Ruan J, Chu KH(*), Liu B(*), Li F(*), Xiang J(*). 2019. Penaeid shrimp genome provides insights into benthic adaptation and frequent molting. Nat Commun 10(1):356. (IF:17.7)

23. Yuan C, Yin Z, Wang J, Qian C, Wei Y, Zhang S, Jiang L(*), Liu B(*). 2019. Comparative genomic analysis of Citrobacter and key genes essential for the pathogenicity of Citrobacter koseri. Front Microbiol 10:2774. (IF:6.1)

24. Liu H, Zhang J, Yuan J, Jiang X, Jiang L, Zhao G, Huang D(*), Liu B(*). 2019. Omics-based analyses revealed metabolic responses of Clostridium acetobutylicum to lignocellulose-derived inhibitors furfural, formic acid and phenol stress for butanol fermentation. Biotechnol Biofuels 12:101. (IF:7.7)

25. Pang Y, Guo X, Tian X, Liu F, Wang L, Wu J, Zhang S, Li S, Liu B(*). 2019. Developing a novel molecular serotyping system based on capsular polysaccharide synthesis gene clusters of Vibrio parahaemolyticus. Int J Food Microbiol 309:108332. (IF:5.9)

26. Wang M, Cao H, Wang Q, Xu T, Guo X, Liu B(*). 2018. The roles of two type VI secretion systems in Cronobacter sakazakii ATCC 12868. Front Microbiol 9:2499. (IF:6.1)

27. Guo X, Wang M, Wang L, Wang Y, Chen T, Wu P, Chen M, Liu B(*), Feng L(*). 2018. Establishment of a molecular serotyping scheme and a multiplexed Luminex-based array for Enterobacter aerogenes. Front Microbiol 9:501. (IF:6.1)

28. Xu T, Cao H, Zhu W, Wang M, Du Y, Yin Z, Chen M, Liu Y, Yang B, Liu B(*). 2018. RNA-seq-based monitoring of gene expression changes of viable but non-culturable state of Vibrio cholerae induced by cold sea water. Environ Microbiol Rep 10(5):594-604. (IF:4.0)

29. Huang D, Yang K, Liu J, Xu Y, Wang Y, Wang R, Liu B(*), Feng L(*). 2017. Metabolic engineering of Escherichia coli for the production of 2’-fucosyllactose and 3-fucosyllactose through modular pathway enhancement. Metab Eng 41: 23-38. (IF:8.8)

30. Liu B, Knirel YA, Feng L, Perepelov AV, Senchenkova SN, Reeves PR, Wang L. 2014. Structural diversity in Salmonella O antigens and its genetic basis. FEMS Microbiol Rev 38(1):56-89. (IF:15.2)

31. Bin Liu, Hu B, Zhou Z, Guo D, Guo X, Ding P, Feng L, Wang L. 2012. A novel nonhomologous recombination-mediated mechanism for Escherichia coli unilateral flagellar phase variation. Nucleic Acids Res 40(10):4530-4538. (IF:19.2)

32. Bin Liu, Chen M, Perepelov AV, Liu J, Ovchinnikova OG, Zhou D, Feng L, Rozalski A, Knirel YA, Wang L. 2012. Genetic analysis of the O-antigen of Providencia alcalifaciens O30 and biochemical characterization of a formyltransferase involved in the synthesis of a Qui4N derivative. Glycobiology 22(9):1236-1244. (IF:6.0)

33. Liu B(#), Perepelov AV(#), Svensson MV(#), Shevelev SD, Guo D, Senchenkova SN, Shashkov AS, Weintraub A, Feng L, Widmalm G, Knirel YA, Wang L. 2010. Genetic and structural relationships of Salmonella O55 and Escherichia coli O103 O-antigens and identification of a 3-hydroxybutanoyltransferase gene involved in the synthesis of a Fuc3N derivative. Glycobiology 20(6):679-688. (IF:6.0)

34. Liu B, Knirel YA, Feng L, Perepelov AV, Senchenkova SN, Wang Q, Reeves PR, Wang L. 2008. Structure and genetics of Shigella O antigens. FEMS Microbiol Rev 32(4): 627-653. (IF:15.2)