姓名：李凤娥

职称：副主任医师

导师类型：硕士研究生导师

1. 教育经历

2010.8.26-2015.7.10 联合培养博士(Ph.D.)，天津医科大学和美国达克萨斯大学MD安德森肿瘤研究中心联合培养，硕博连读，肿瘤学博士

（2013.8.12-2014.10美国德克萨斯大学MD安德森癌症中心，黑色素

瘤医学肿瘤研究部，国家公派联合培养博士，肿瘤免

疫学）

2005.9.1-2010.7.1  本科学位(M.D.)，山东省济宁医学院，临床医学

2. 工作经历

2021.10-至今    副主任医师，天津市北辰医院肿瘤科

2020.1-2021.10  博士后，美国MD安德森癌症中心，黑色素瘤医学

瘤研究部

2017.2-2020.1   博士后，美国贝勒医学院HuffingtonCenter研究中心

2015.7-2017.2   外科住院医师，天津市第一中心医院，妇科肿瘤组

3. 研究方向（可以填写多个方向）

• 肿瘤化学治疗耐药分子机制研究

• 肿瘤免疫治疗（TIL/肿瘤新抗原疫苗、个体化多肽疫苗、 TCR克隆、TCR-T等抗肿瘤疗效基础和临床转化研究）

• 抗肿瘤药物临床转化研究（肿瘤新抗原疫苗临床试验研究）

• 肿瘤新靶点治疗药物研发（靶点筛选，细胞信号通路研究）

4. 学术兼职

天津市中西医结合学会抗肿瘤专业委员会委员

审稿编辑
SectionEditor （2020-至今）

Archivesof Medical Science

客座编辑（2014-2015）

GeneRegulation and Systems Biology

审稿期刊
Journalof Hematology and Oncology Research
Journal of BiologicalMethods
Clinical Genetics
Molecular and CellularBiochemistry
Molecular Medicine Reports
OncologyReports
Archives of Medical Science
Stem CellInternational
Oncology Letters
International Journal ofOncology
Oncotarget

5. 代表性学术论文

[1]Li F,Guo Z, Wang H. Influencing elements and treatment strategiesassociated with the relapse of hepatocellular carcinoma aftersurgery. Hepatogastroenterology. 2013 Jul-Aug;60(125):1148-55.

[2]LiF, Guo Z, Lizée G, YuH, Wang H, Si T. Clinical prognostic value ofCD4+CD25+FOXP3+regulatory T cells in peripheral blood of BarcelonaClinic Liver Cancer (BCLC) stage B hepatocellular carcinoma patients.Clin Chem Lab Med. 2014 59(9);1357-1365. 【2014-IF:2.707】

[3]Li F,Guo Z, Yu H, Zhang X, Si T, Liu C, Yang X, Qi L. Anti-tumorimmunological response induced by cryoablation and anti-CTLA-4antibody in an in vivo RM-1 cell prostate cancer murine model.Neoplasma, 2014,61(6): 659-71. 【2014-IF:1.865】

[4]Li F,Guo Z, Zhang Y, Wang H, Zhang X, Si T, Yu H, Qi L. Postoperativeadjuvant arterial chemoembolization improves survival of hepatitis Bvirus-related hepatocellular carcinoma: a retrospective controlstudy. Ir J Med Sci. 2015 Dec;184(4):753-9. 【2015-IF:1.158】

[5]Qu J, Yu H, LiF(Co-first author),Zhang C, Trad A, Brooks C, Zhang B, Gong T, Guo Z, Li Y, Ragupathi G,Lou Y, Hwu P, Huang W, Zhou D. Molecular basis of antibody binding tomucin glycopeptides in lung cancer. Int J Oncol. 2016Feb;48(2):587-94.【2016-IF:3.079】

[6]Li F,Chen C, Ju T, Gao J, Yan J, Wang P, Xu Q, Hwu P, Du X, Lizée G.Rapid tumor regression in an Asian lung cancer patient followingpersonalized neo-epitope peptide vaccination. Oncoimmunology. 2016Oct 7;5(12):e1238539. 【2016-IF:7.719】

[7]Li F,Du X, Zhang H, Ju T, Chen C, Qu Q, Zhang X, Qi L, Lizée G. NextGeneration Sequencing of Chinese Stage IV Lung Cancer PatientsReveals an Association between EGFR Mutation Status and SurvivalOutcome. Clin Genet. 2017 Mar;91(3):488-493. 【2016-IF:3.512】

[8]Li F,Jiang D, Samuel MA. Microglia in the developing retina. Neural Dev.2019 Dec 30;14(1):12. doi: 10.1186/s13064-019-0137-x.【2019-IF:2.63】

[9]Yan Lan, Shuo Zhou, Weihong Feng, Ying Qiao , Xueming Du , FengeLi (Co-corresponding author).Association of tumor mutation burden and EGFR inhibitor history withsurvival in patients with metastatic stage III/IV non-small cell LungCancer. CLINICS (Sao Paulo) 2021; 76: e2251.DOI: 10.6061/clinics/2021/e2251【2020-IF:2.365】

[10]Fenge Li,Liping Wang, Yixiang Zhang, Weihong Feng, Tao Ju, Zaiping Liu,Zhenglu Wang, Xueming Du. A retrospective study on using a novelsingle needle cone puncture approach for the Iodine-125 seedbrachytherapy in treating patients with thoracic malignancy.Frontiers in Oncology, 2021;11: 640131.doi: 10.3389/fonc.2021.640131【2021-IF:6.244】

[11]Ravi G. Gupta, FengeLi, Jason Roszik,Gregory Lizee. Exploiting tumor Neoantigens to target cancerevolution: current challenges and promising therapeutic approaches.Cancer Discovery,2021; 11: 1-16.DOI:10.1158/2159-8290.CD-20-1575 【2021-IF:39.397】

[12]FengeLi, Ligang Deng, AmjadH. Talukder, Kyle R. Jackson, Arjun Katailiha, Sherille D. Bradley,Heather Sonnemann, Qingwei Zou, Caixia Chen, Chong Huo,Yulun Chiu1,Matthew Stair, Weihong Feng, Aleksander Bagaev, Nikita Kotlov, ViktorSvekolkin, Ravshan Ataullakhanov, Natalia Miheecheva, Felix Frenkel,Yaling Wang, Minying Zhang, David Hawke, Jason Roszik, Ling Han, ShuoZhou, Yan Zhang, Zhenglu Wang, Patrick Hwu, Xueming Du, and GregoryLizée.Neoantigenvaccination induces clinical and immunologic responses in non-smallcell lung cancer patients harboring EGFR mutations. J ImmunotherCancer 2021;9:e002531【2021-IF:13.751】

13. FengeLi, Yimo Sun, HeatherSonnemann, Kyle R. Jackson, Amjad H. Talukder, Arjun S. Katailiha,Gregory Lizee. Evolutionof CD8+ T Cell Receptor (TCR) Engineered Therapies for theTreatment of Cancer. Cells. 2021 Sep; 10(9): 2379.【2021-IF:6.6】

6. 荣誉和奖励

2013.8-2014.10中国国家留学基金委奖学金
2008.10国家励志奖学金

7. 联系方式

联系邮箱：rosetea85@163.com

联系地址：天津市北辰区北医道7号北辰医院A座14楼